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Open Access
Peer-reviewed
Research Article
Multiview deep-learning-enabled histopathology for prognostic and therapeutic stratification in stage II colorectal cancer: A retrospective multicenter study
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Zihan Zhao ,
Contributed equally to this work with: Zihan Zhao, Dexia Chen, Ruixuan Wang, Xinke Zhang
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Dexia Chen ,
Contributed equally to this work with: Zihan Zhao, Dexia Chen, Ruixuan Wang, Xinke Zhang
Roles Methodology, Validation, Writing – original draft, Writing – review & editing
Affiliation School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, Guangdong, China
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Ruixuan Wang ,
Contributed equally to this work with: Zihan Zhao, Dexia Chen, Ruixuan Wang, Xinke Zhang
Roles Conceptualization, Software, Visualization, Writing – original draft, Writing – review & editing
Affiliation School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, Guangdong, China
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Xinke Zhang ,
Contributed equally to this work with: Zihan Zhao, Dexia Chen, Ruixuan Wang, Xinke Zhang
Roles Data curation, Funding acquisition
Affiliation Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Xiaobo Wen,
Roles Data curation
Affiliation Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Xueyi Zheng,
Roles Writing – review & editing
Affiliation Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Shasha Liu,
Roles Data curation
Affiliation Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
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Hao Chen,
Roles Data curation
Affiliation Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
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Yuqian Zhang,
Roles Methodology
Affiliation Electrical Engineering & Computer Science, Johns Hopkins University, Baltimore, Maryland, United States of America
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Dan Huang,
Roles Data curation
Affiliation Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
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Chengyou Zheng,
Roles Data curation
Affiliation Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Mengke Ma,
Roles Data curation
Affiliation Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
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Dan Xie ,
Roles Methodology, Writing – review & editing
* E-mail: xiedan@sysucc.org.cn (DX); sunyan@tjmuch.com (YS); hexsheng@mail.sysu.edu.cn (XH); caimy@sysucc.org.cn (MC)
Affiliation Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Yan Sun ,
Roles Conceptualization, Data curation
* E-mail: xiedan@sysucc.org.cn (DX); sunyan@tjmuch.com (YS); hexsheng@mail.sysu.edu.cn (XH); caimy@sysucc.org.cn (MC)
Affiliation Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
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Xiaosheng He ,
Roles Conceptualization, Data curation
* E-mail: xiedan@sysucc.org.cn (DX); sunyan@tjmuch.com (YS); hexsheng@mail.sysu.edu.cn (XH); caimy@sysucc.org.cn (MC)
Affiliation Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
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Muyan Cai
Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing
* E-mail: xiedan@sysucc.org.cn (DX); sunyan@tjmuch.com (YS); hexsheng@mail.sysu.edu.cn (XH); caimy@sysucc.org.cn (MC)
Affiliation Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
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Multiview deep-learning-enabled histopathology for prognostic and therapeutic stratification in stage II colorectal cancer: A retrospective multicenter study
- Zihan Zhao,
- Dexia Chen,
- Ruixuan Wang,
- Xinke Zhang,
- Xiaobo Wen,
- Xueyi Zheng,
- Shasha Liu,
- Hao Chen,
- Yuqian Zhang,
- Dan Huang
- Published: January 13, 2026
- https://doi.org/10.1371/journal.pmed.1004614