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Open Access
Peer-reviewed
Research Article
Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study
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Zhiwei Guo ,
Contributed equally to this work with: Zhiwei Guo, Ke Wang, Xiang Huang
Roles Investigation
Affiliations Department of Obstetrics and Gynaecology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, China, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou, China, Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
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Ke Wang ,
Contributed equally to this work with: Zhiwei Guo, Ke Wang, Xiang Huang
Roles Data curation
Affiliation Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou, China
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Xiang Huang ,
Contributed equally to this work with: Zhiwei Guo, Ke Wang, Xiang Huang
Roles Data curation
Affiliation Prenatal Diagnosis Center, Foshan Women and Children Hospital, Foshan, Guangdong, China
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Kun Li,
Roles Methodology
Affiliation Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
⨯ - Guojun Ouyang,
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Xu Yang,
Roles Data curation
Affiliation Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
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Jiayu Tan,
Roles Data curation
Affiliation Emergency Department, Foshan Women and Children Hospital, Foshan, Guangdong, China
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Haihong Shi,
Roles Data curation
Affiliation Medical Genetics Center, Jiangmen Maternity and Child Health Care Hospital, Jiangmen, Guangdong, China
⨯ - Liangping Luo,
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Min Zhang,
Roles Formal analysis, Methodology
Affiliation Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
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Bowei Han,
Roles Formal analysis, Visualization
Affiliation Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
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Xiangming Zhai,
Roles Formal analysis
Affiliation Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
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Jinhai Deng,
Roles Writing – review & editing
Affiliation Richard Dimbleby Department of Cancer Research, Comprehensive Cancer Centre, Kings College London, London, United Kingdom
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Richard Beatson,
Roles Writing – review & editing
Affiliation King’s College London, School of Cancer and Pharmaceutical Sciences, Guy’s Cancer Centre, London, United Kingdom
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Yingsong Wu ,
Roles Conceptualization, Supervision
* E-mail: wg@smu.edu.cn (YW); 964175870@qq.com (FY); yxx1214@smu.edu.cn (XY); tony2081129@163.com (JT)
Affiliation Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
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Fang Yang ,
Roles Data curation
* E-mail: wg@smu.edu.cn (YW); 964175870@qq.com (FY); yxx1214@smu.edu.cn (XY); tony2081129@163.com (JT)
Affiliation Department of Fetal Medicine and Prenatal Diagnosis, Zhujiang Hospital, Southern Medical University, Guangzhou, China
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Xuexi Yang ,
Roles Conceptualization, Project administration, Supervision
* E-mail: wg@smu.edu.cn (YW); 964175870@qq.com (FY); yxx1214@smu.edu.cn (XY); tony2081129@163.com (JT)
Affiliation Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China
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Jia Tang
Roles Data curation, Funding acquisition, Project administration, Supervision, Conceptualization
* E-mail: wg@smu.edu.cn (YW); 964175870@qq.com (FY); yxx1214@smu.edu.cn (XY); tony2081129@163.com (JT)
Affiliations NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou, China, Medical Genetics Center, Jiangmen Maternity and Child Health Care Hospital, Jiangmen, Guangdong, China, School of Medicine, Jinan University, Guangzhou, China, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study
- Zhiwei Guo,
- Ke Wang,
- Xiang Huang,
- Kun Li,
- Guojun Ouyang,
- Xu Yang,
- Jiayu Tan,
- Haihong Shi,
- Liangping Luo,
- Min Zhang
- Published: April 15, 2025
- https://doi.org/10.1371/journal.pmed.1004571