Predicting patent challenges for small-molecule drugs: A cross-sectional study

Ally Memedovich; Brian Steele; Taylor Orr; Shanzeh Chaudhry; Mina Tadrous; Aaron S. Kesselheim; Aidan Hollis; Reed F. Beall

doi:10.1371/journal.pmed.1004540

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Open Access

Peer-reviewed

Research Article

Predicting patent challenges for small-molecule drugs: A cross-sectional study

Ally Memedovich,

Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

https://orcid.org/0000-0003-3193-8088

⨯
Brian Steele,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
⨯
Taylor Orr,

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
⨯
Shanzeh Chaudhry,

Roles Data curation, Resources, Writing – review & editing

Affiliation Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
⨯
Mina Tadrous,

Roles Conceptualization, Data curation, Resources, Writing – review & editing

Affiliation Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

https://orcid.org/0000-0003-1911-6129

⨯
Aaron S. Kesselheim,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-8867-2666

⨯
Aidan Hollis,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Economics, University of Calgary, Calgary, Alberta, Canada

https://orcid.org/0000-0001-5125-2193

⨯
Reed F. Beall

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Software, Supervision, Visualization, Writing – review & editing

* E-mail: Reed.Beall@ucalgary.ca

Affiliation Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

https://orcid.org/0000-0001-8188-7616

⨯

Predicting patent challenges for small-molecule drugs: A cross-sectional study

Ally Memedovich,
Brian Steele,
Taylor Orr,
Shanzeh Chaudhry,
Mina Tadrous,
Aaron S. Kesselheim,
Aidan Hollis,
Reed F. Beall

Published: February 12, 2025
https://doi.org/10.1371/journal.pmed.1004540

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