Polygenic risk scores for pan-cancer risk prediction in the Chinese population: A population-based cohort study based on the China Kadoorie Biobank

• Meng Zhu ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share co-first authorship on this work.

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China, Department of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, China

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• Xia Zhu ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share co-first authorship on this work.

  Affiliation Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

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• Yuting Han ,

  Roles Data curation, Investigation, Methodology, Resources, Validation, Writing – review & editing

  ¶‡ These authors share co-first authorship on this work.

  Affiliation Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China

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• Zhimin Ma,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

  https://orcid.org/0000-0002-1354-1055

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• Chen Ji,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

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• Tianpei Wang,

  Roles Investigation, Methodology, Software

  Affiliation Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

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• Caiwang Yan,

  Roles Investigation, Methodology, Resources

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China, Department of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, China

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• Ci Song,

  Roles Investigation, Methodology, Resources

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China, Department of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, China

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• Canqing Yu,

  Roles Data curation, Investigation, Methodology, Resources

  Affiliations Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China, Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China, Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China

  https://orcid.org/0000-0002-0019-0014

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• Dianjianyi Sun,

  Roles Investigation, Methodology, Resources

  Affiliations Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China, Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China, Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China

  https://orcid.org/0000-0003-3651-6693

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• Yue Jiang,

  Roles Investigation, Methodology, Resources

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China

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• Jiaping Chen,

  Roles Investigation, Methodology, Resources

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China

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• Ling Yang,

  Roles Investigation, Methodology, Resources, Software

  Affiliations Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0001-5750-6588

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• Yiping Chen,

  Roles Investigation, Methodology, Resources, Software

  Affiliations Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

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• Huaidong Du,

  Roles Investigation, Methodology, Resources, Software

  Affiliations Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0002-9814-0049

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• Robin Walters,

  Roles Investigation, Methodology, Resources, Software

  Affiliations Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0002-9179-0321

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• Iona Y Millwood,

  Roles Investigation, Methodology, Resources, Software

  Affiliations Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

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• Juncheng Dai,

  Roles Methodology, Resources, Software

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China, Genomic Science and Precision Medicine Institute, Gusu School, Nanjing Medical University, Nanjing, China

  https://orcid.org/0000-0002-3909-5671

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• Hongxia Ma,

  Roles Methodology, Resources, Software

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China, Genomic Science and Precision Medicine Institute, Gusu School, Nanjing Medical University, Nanjing, China

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• Zhengdong Zhang,

  Roles Methodology, Resources, Software

  Affiliation Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China

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• Zhengming Chen,

  Roles Methodology, Resources, Software

  Affiliation Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

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• Zhibin Hu,

  Roles Methodology, Resources, Software

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China

  https://orcid.org/0000-0002-8277-5234

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• Jun Lv,

  Roles Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software

  Affiliations Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China, Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China, Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China

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• Guangfu Jin ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: guangfujin@njmu.edu.cn (GJ); lmlee@bjmu.edu.cn (LL); hbshen@njmu.edu.cn (HS)

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China, Department of Chronic Non-Communicable Disease Control, The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi Medical Center, Nanjing Medical University, Wuxi, China

  https://orcid.org/0000-0003-0249-5337

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• Liming Li ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: guangfujin@njmu.edu.cn (GJ); lmlee@bjmu.edu.cn (LL); hbshen@njmu.edu.cn (HS)

  Affiliations Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China, Peking University Center for Public Health and Epidemic Preparedness & Response, Beijing, China, Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China

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• Hongbing Shen ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: guangfujin@njmu.edu.cn (GJ); lmlee@bjmu.edu.cn (LL); hbshen@njmu.edu.cn (HS)

  Affiliations Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine and China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China

  https://orcid.org/0000-0002-2581-5906

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•  [ ... ],
• on behalf of the China Kadoorie Biobank Collaborative Group

  ¶Members of the China Kadoorie Biobank Collaborative Group are provided in the Supporting information (S4 Text).

  Affiliation Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China

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