New pharmacodynamic parameters linked with ibrutinib responses in chronic lymphocytic leukemia: Prospective study in real-world patients and mathematical modeling

• Sarah Cadot ,

  Contributed equally to this work with: Sarah Cadot, Chloe Audebert, Fabien Crauste, Anne Quillet-Mary

  Roles Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations INSERM UMR1037, CNRS UMR5071, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France, Laboratoire d’Excellence ’TOUCAN-2’, Toulouse, France

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• Chloe Audebert ,

  Contributed equally to this work with: Sarah Cadot, Chloe Audebert, Fabien Crauste, Anne Quillet-Mary

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Sorbonne Université, CNRS, Université Paris Cité, Laboratoire Jacques-Louis Lions UMR 7598, Paris, France, Sorbonne Université, CNRS, Institut de Biologie Paris-Seine, Laboratoire de Biologie Computationnelle et Quantitative UMR 7238, Paris, France

  https://orcid.org/0000-0002-0914-2107

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• Charlotte Dion,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Sorbonne Université, UMR CNRS 8001, LPSM, Paris, France

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• Soleakhena Ken,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliations INSERM UMR1037, CNRS UMR5071, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France, Institut Claudius Regaud- Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France

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• Loic Dupré,

  Roles Funding acquisition, Writing – review & editing

  Affiliations Institut Toulousain des Maladies Infectieuses et Inflammatoires, INSERM, CNRS, Université Toulouse III-Paul Sabatier, Toulouse, France, Department of Dermatology, Medical University of Vienna, Vienna, Austria

  https://orcid.org/0000-0002-7278-6503

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• Laetitia Largeaud,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations INSERM UMR1037, CNRS UMR5071, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France, Institut Universitaire du Cancer-Oncopole de Toulouse, Toulouse, France

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• Camille Laurent,

  Roles Writing – review & editing

  Affiliations INSERM UMR1037, CNRS UMR5071, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France, Laboratoire d’Excellence ’TOUCAN-2’, Toulouse, France, Institut Universitaire du Cancer-Oncopole de Toulouse, Toulouse, France

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• Loic Ysebaert,

  Roles Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliations INSERM UMR1037, CNRS UMR5071, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France, Laboratoire d’Excellence ’TOUCAN-2’, Toulouse, France, Institut Universitaire du Cancer-Oncopole de Toulouse, Toulouse, France

  https://orcid.org/0000-0003-4102-7261

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• Fabien Crauste ,

  Contributed equally to this work with: Sarah Cadot, Chloe Audebert, Fabien Crauste, Anne Quillet-Mary

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Université Paris Cité, CNRS, MAP5 UMR 8145, Paris, France

  https://orcid.org/0000-0002-9979-9638

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• Anne Quillet-Mary

  Contributed equally to this work with: Sarah Cadot, Chloe Audebert, Fabien Crauste, Anne Quillet-Mary

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: anne.quillet-mary@inserm.fr

  Affiliations INSERM UMR1037, CNRS UMR5071, Université Toulouse III-Paul Sabatier, Centre de Recherches en Cancérologie de Toulouse, Toulouse, France, Laboratoire d’Excellence ’TOUCAN-2’, Toulouse, France

  https://orcid.org/0000-0002-1849-6388

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