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Open Access
Peer-reviewed
Research Article
Brain-based measures of nociception during general anesthesia with remifentanil: A randomized controlled trial
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Keerthana Deepti Karunakaran ,
Contributed equally to this work with: Keerthana Deepti Karunakaran, Barry D. Kussman
Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing
Affiliation The Center for Pain and the Brain, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Barry D. Kussman ,
Contributed equally to this work with: Keerthana Deepti Karunakaran, Barry D. Kussman
Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Supervision, Writing – review & editing
Affiliation Division of Cardiac Anesthesia, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Ke Peng,
Roles Data curation, Methodology, Writing – review & editing
Affiliations The Center for Pain and the Brain, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Département en Neuroscience, Centre de Recherche du CHUM, l’Université de Montréal Montreal, Québec, Canada
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Lino Becerra,
Roles Conceptualization, Investigation, Resources, Supervision, Writing – review & editing
Affiliation The Center for Pain and the Brain, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Robert Labadie,
Roles Data curation, Formal analysis, Writing – review & editing
Affiliation The Center for Pain and the Brain, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Rachel Bernier,
Roles Data curation, Project administration, Writing – review & editing
Affiliation Division of Cardiac Anesthesia, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Delany Berry,
Roles Data curation, Formal analysis, Resources, Writing – review & editing
Affiliation The Center for Pain and the Brain, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Stephen Green,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliation The Center for Pain and the Brain, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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David Zurakowski,
Roles Conceptualization, Methodology, Writing – review & editing
Affiliation Division of Biostatistics, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Mark E. Alexander,
Roles Conceptualization, Data curation, Project administration, Writing – review & editing
Affiliation Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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David Borsook
Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: dborsook@mgh.harvard.edu
Affiliations The Center for Pain and the Brain, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Psychiatry and Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Brain-based measures of nociception during general anesthesia with remifentanil: A randomized controlled trial
- Keerthana Deepti Karunakaran,
- Barry D. Kussman,
- Ke Peng,
- Lino Becerra,
- Robert Labadie,
- Rachel Bernier,
- Delany Berry,
- Stephen Green,
- David Zurakowski,
- Mark E. Alexander
![PLOS](/resource/img/logo-plos.png)
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- Published: April 22, 2022
- https://doi.org/10.1371/journal.pmed.1003965