Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

• Vijay R. Varma ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America

  https://orcid.org/0000-0001-7143-7726

  ⨯
• Youjin Wang ,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliation Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Yang An,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Brain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America

  ⨯
• Sudhir Varma,

  Roles Data curation, Formal analysis, Visualization

  Affiliation HiThru Analytics, Laurel, Maryland, United States of America

  https://orcid.org/0000-0002-4096-4782

  ⨯
• Murat Bilgel,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Brain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America

  https://orcid.org/0000-0001-5042-7422

  ⨯
• Jimit Doshi,

  Roles Data curation, Methodology

  Affiliation Section for Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Cristina Legido-Quigley,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Kings College London, United Kingdom

  https://orcid.org/0000-0002-4018-214X

  ⨯
• João C. Delgado,

  Roles Writing – review & editing

  Affiliation College of Medicine and Health, University of Exeter, Exeter, United Kingdom

  https://orcid.org/0000-0003-1648-871X

  ⨯
• Anup M. Oommen,

  Roles Methodology, Writing – review & editing

  Affiliation Glycoscience Group, NCBES National Centre for Biomedical Engineering Science, National University of Ireland Galway, Galway, Ireland

  https://orcid.org/0000-0001-7653-5106

  ⨯
• Jackson A. Roberts,

  Roles Data curation, Visualization

  Affiliation Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-2231-2454

  ⨯
• Dean F. Wong,

  Roles Data curation, Methodology

  Affiliation Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Christos Davatzikos,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Section for Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

  ⨯
• Susan M. Resnick,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Brain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America

  ⨯
• Juan C. Troncoso,

  Roles Data curation, Investigation

  Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0001-9553-6673

  ⨯
• Olga Pletnikova,

  Roles Data curation, Methodology

  Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

  ⨯
• Richard O’Brien,

  Roles Investigation

  Affiliation Department of Neurology, Duke University School of Medicine, Durham, North Carolina, United States of America

  https://orcid.org/0000-0002-4463-158X

  ⨯
• Eelko Hak,

  Roles Writing – review & editing

  Affiliation Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands

  ⨯
• Brenda N. Baak,

  Roles Writing – review & editing

  Affiliation Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands

  ⨯
• Ruth Pfeiffer,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Priyanka Baloni,

  Roles Data curation, Writing – review & editing

  Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-3382-4941

  ⨯
• Siamak Mohmoudiandehkordi,

  Roles Data curation

  Affiliation Department of Psychiatry and Behavioral Sciences, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

  https://orcid.org/0000-0002-6843-1718

  ⨯
• Kwangsik Nho,

  Roles Data curation

  Affiliation Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

  https://orcid.org/0000-0002-7624-3872

  ⨯
• Rima Kaddurah-Daouk,

  Roles Writing – review & editing

  Affiliation Department of Psychiatry and Behavioral Sciences, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

  https://orcid.org/0000-0003-1858-5732

  ⨯
• David A. Bennett,

  Roles Writing – review & editing

  Affiliation Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America

  https://orcid.org/0000-0003-3689-554X

  ⨯
• Shahinaz M. Gadalla,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-3255-8143

  ⨯
•  [ ... ],
• Madhav Thambisetty

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: thambisettym@mail.nih.gov

  Affiliation Clinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging (NIA), National Institutes of Health (NIH), Baltimore, Maryland, United States of America

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