The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual-patient meta-analysis

• Andria Mousa ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: a.mousa17@imperial.ac.uk

  Affiliation MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0001-9406-7481

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• Abdullah Al-Taiar,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation School of Community & Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, Virginia, United States of America

  http://orcid.org/0000-0001-7421-3381

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• Nicholas M. Anstey,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia

  ⨯
• Cyril Badaut,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Unité de Biothérapie Infectieuse et Immunité, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France, Unité des Virus Emergents (UVE: Aix-Marseille Univ—IRD 190—Inserm 1207—IHU Méditerranée Infection), Marseille, France

  http://orcid.org/0000-0002-0064-6384

  ⨯
• Bridget E. Barber,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

  http://orcid.org/0000-0003-1066-7960

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• Quique Bassat,

  Roles Conceptualization, Data curation, Resources, Writing – review & editing

  Affiliations ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain, Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique, ICREA, Barcelona, Spain, Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu (University of Barcelona), Barcelona, Spain, Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

  http://orcid.org/0000-0003-0875-7596

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• Joseph D. Challenger,

  Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0001-6029-1733

  ⨯
• Aubrey J. Cunnington,

  Roles Conceptualization, Data curation, Resources, Writing – review & editing

  Affiliation Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, United Kingdom

  http://orcid.org/0000-0002-1305-3529

  ⨯
• Dibyadyuti Datta,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

  http://orcid.org/0000-0002-1693-935X

  ⨯
• Chris Drakeley,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

  http://orcid.org/0000-0003-4863-075X

  ⨯
• Azra C. Ghani,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0002-0007-4910

  ⨯
• Victor R. Gordeuk,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Sickle Cell Center, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

  http://orcid.org/0000-0003-4725-7295

  ⨯
• Matthew J. Grigg,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia

  http://orcid.org/0000-0001-9914-8352

  ⨯
• Pierre Hugo,

  Roles Conceptualization, Writing – review & editing

  Affiliation Medicines for Malaria Venture, Geneva, Switzerland

  http://orcid.org/0000-0001-6489-4531

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• Chandy C. John,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

  http://orcid.org/0000-0002-1634-1411

  ⨯
• Alfredo Mayor,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain, Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique, Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

  http://orcid.org/0000-0003-3890-2897

  ⨯
• Florence Migot-Nabias,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Université de Paris, MERIT, IRD, Paris, France

  http://orcid.org/0000-0001-9982-594X

  ⨯
• Robert O. Opoka,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Paediatrics and Child Health, Makerere University School of Medicine, Kampala, Uganda

  ⨯
• Geoffrey Pasvol,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Imperial College London, Department of Life Sciences, London, United Kingdom

  ⨯
• Claire Rees,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Centre for Global Public Health, Institute of Population Health Sciences, Barts & The London School of Medicine & Dentistry, London, United Kingdom

  http://orcid.org/0000-0001-5649-7835

  ⨯
• Hugh Reyburn,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

  ⨯
• Eleanor M. Riley,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Binal N. Shah,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Sickle Cell Center, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

  http://orcid.org/0000-0001-5169-7301

  ⨯
• Antonio Sitoe,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique

  ⨯
• Colin J. Sutherland,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

  http://orcid.org/0000-0003-1592-6407

  ⨯
• Philip E. Thuma,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Macha Research Trust, Choma, Zambia

  http://orcid.org/0000-0002-1508-4409

  ⨯
• Stefan A. Unger,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Department of Child Life and Health, University of Edinburgh, United Kingdom, Department of Respiratory Medicine, Royal Hospital for Sick Children, Edinburgh, United Kingdom

  http://orcid.org/0000-0001-7089-5063

  ⨯
• Firmine Viwami,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Institut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin

  ⨯
• Michael Walther,

  Roles Data curation, Resources, Writing – review & editing

  Current address: Untere Grabenstraße, Leutkirch, Germany.

  Affiliation Medical Research Council Unit, Fajara, The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia

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• Christopher J. M. Whitty,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

  ⨯
• Timothy William,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research Unit, Kota Kinabalu, Sabah, Malaysia, Gleneagles Hospital, Kota Kinabalu, Sabah, Malaysia

  ⨯
•  [ ... ],
• Lucy C. Okell

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0001-7202-6873

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