Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium

• Signe Hässler ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

  * E-mail: signe.hassler@sorbonne-universite.fr (SH); philippe.broet@inserm.fr (PB)

  Affiliations CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, UVSQ, Paris-Saclay University, Villejuif, France, Sorbonne Université, INSERM UMR 959, Immunology-Immunopathology-Immunotherapy (i3), Paris, France, AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi), Paris, France

  https://orcid.org/0000-0003-4263-3079

  ⨯
• Delphine Bachelet,

  Roles Conceptualization, Data curation, Methodology, Visualization, Writing – review & editing

  Affiliations CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, UVSQ, Paris-Saclay University, Villejuif, France, Department of Biostatistical Epidemiology and Clinical Research, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris AP-HP.Nord, INSERM CIC-EC 1425, Paris, France

  https://orcid.org/0000-0003-0547-008X

  ⨯
• Julianne Duhaze,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft

  Affiliations CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, UVSQ, Paris-Saclay University, Villejuif, France, CHU Ste-Justine Research Center, Montreal, Canada

  https://orcid.org/0000-0003-2377-6162

  ⨯
• Natacha Szely,

  Roles Investigation, Writing – review & editing

  Affiliation INSERM UMR 996, Faculty of Pharmacy, Paris-Sud University, Paris-Saclay University, Châtenay-Malabry, France

  ⨯
• Aude Gleizes,

  Roles Investigation, Writing – review & editing

  Affiliations INSERM UMR 996, Faculty of Pharmacy, Paris-Sud University, Paris-Saclay University, Châtenay-Malabry, France, Clinical Immunology Laboratory, AP-HP, Le Kremlin-Bicêtre Hospital, Paris-Sud University Hospitals, Le Kremlin-Bicêtre, France

  ⨯
• Salima Hacein-Bey Abina,

  Roles Investigation, Writing – review & editing

  Affiliations Clinical Immunology Laboratory, AP-HP, Le Kremlin-Bicêtre Hospital, Paris-Sud University Hospitals, Le Kremlin-Bicêtre, France, UTCBS, CNRS UMR 8258, INSERM U1022, Faculty of Pharmacy, Paris-Descartes-Sorbonne-Cite University, Paris, France

  ⨯
• Orhan Aktas,

  Roles Investigation, Writing – review & editing

  Affiliation University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany

  https://orcid.org/0000-0002-2020-9210

  ⨯
• Michael Auer,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Innsbruck Medical University, Department of Neurology, Innsbruck, Austria

  https://orcid.org/0000-0002-5117-4225

  ⨯
• Jerôme Avouac,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Paris University, Paris Descartes University, INSERM U1016, Paris, France, Rheumatology department, Cochin Hospital, AP-HP.CUP, Paris, France

  https://orcid.org/0000-0002-2463-218X

  ⨯
• Mary Birchler,

  Roles Investigation, Writing – review & editing

  Affiliation GlaxoSmithKline, Clinical Immunology–Biopharm, Collegeville, Pennsylvania, United States of America

  ⨯
• Yoram Bouhnik,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations AP-HP, Hôpital Beaujon, Paris, France, GETAID, Paris, France

  ⨯
• Olivier Brocq,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Princess Grace Hospital, Rheumatology, Monaco

  ⨯
• Dorothea Buck-Martin,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Neurology, Technische Universität München, Munich, Germany

  ⨯
• Guillaume Cadiot,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations GETAID, Paris, France, Service d'hépato-gastroentérologie, University Hospital of Reims, Reims, France

  ⨯
• Franck Carbonnel,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations GETAID, Paris, France, Department of Gastroenterology, AP-HP, Hôpital Kremlin-Bicêtre, France

  ⨯
• Yehuda Chowers,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel; Clinical Research Institute, Rambam Health Care Campus, Haifa, Israel

  ⨯
• Manuel Comabella,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat). Institut de Recerca Vall d’Hebron (VHIR). Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

  https://orcid.org/0000-0002-2373-6657

  ⨯
• Tobias Derfuss,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland

  ⨯
• Niek De Vries,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Rheumatology & Clinical Immunology, Amsterdam UMC | AMC, University of Amsterdam, Amsterdam, the Netherlands

  https://orcid.org/0000-0002-6257-8604

  ⨯
• Naoimh Donnellan,

  Roles Data curation, Writing – review & editing

  Affiliation Ipsen Biopharm Ltd, Berkshire, United Kingdom

  ⨯
• Abiba Doukani,

  Roles Investigation, Writing – review & editing

  Affiliation Sorbonne Université, Inserm, UMS Production et Analyse des données en Sciences de la vie et en Santé, UMS 37 PASS, Plateforme Post-génomique de la Pitié-Salpêtrière, P3S, Paris, France

  ⨯
• Michael Guger,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Clinic for Neurology 2, Med Campus III, Kepler University Hospital GmbH, Linz, Austria

  https://orcid.org/0000-0001-8219-781X

  ⨯
• Hans-Peter Hartung,

  Roles Investigation, Writing – review & editing

  Affiliation University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany

  ⨯
• Eva Kubala Havrdova,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

  https://orcid.org/0000-0002-9543-4359

  ⨯
• Bernhard Hemmer,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Department of Neurology, Technische Universität München, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

  ⨯
• Tom Huizinga,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands

  ⨯
• Kathleen Ingenhoven,

  Roles Investigation, Writing – review & editing

  Affiliation University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany

  ⨯
• Poul Erik Hyldgaard-Jensen,

  Roles Investigation, Writing – review & editing

  Affiliation Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

  ⨯
• Elizabeth C. Jury,

  Roles Investigation, Writing – review & editing

  Affiliation Centre for Rheumatology Research, University College London, London, United Kingdom

  https://orcid.org/0000-0002-2389-3396

  ⨯
• Michael Khalil,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Neurology, Medical University of Graz, Austria

  https://orcid.org/0000-0002-5350-3328

  ⨯
• Bernd Kieseier,

  Roles Investigation, Writing – review & editing

  Affiliation University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany

  ⨯
• Anna Laurén,

  Roles Investigation, Writing – review & editing

  Affiliation Svar Life Science, Malmö, Sweden

  ⨯
• Raija Lindberg,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland

  https://orcid.org/0000-0003-3349-314X

  ⨯
• Amy Loercher,

  Roles Investigation, Writing – review & editing

  Affiliation GlaxoSmithKline, Clinical Immunology–Biopharm, Collegeville, Pennsylvania, United States of America

  https://orcid.org/0000-0001-8353-7441

  ⨯
• Enrico Maggi,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Dipartimento di Medicina Sperimentale e Clínica, Università di Firenze, Firenze, Italy, Immunology Area of Bambino Gesù Pediatric Hospital, IRCCS, Rome, Italy

  ⨯
• Jessica Manson,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Rheumatology, University College London Hospital, London, United Kingdom

  https://orcid.org/0000-0002-1209-4417

  ⨯
• Claudia Mauri,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Centre for Rheumatology Research, University College London, London, United Kingdom

  ⨯
• Badreddine Mohand Oumoussa,

  Roles Investigation, Writing – review & editing

  Affiliation Sorbonne Université, Inserm, UMS Production et Analyse des données en Sciences de la vie et en Santé, UMS 37 PASS, Plateforme Post-génomique de la Pitié-Salpêtrière, P3S, Paris, France

  ⨯
• Xavier Montalban,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat). Institut de Recerca Vall d’Hebron (VHIR). Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain, Center for Multiple Sclerosis, St. Michael's Hospital, University of Toronto, Toronto, Canada

  ⨯
• Maria Nachury,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations GETAID, Paris, France, University hospital of Lille, Maladies de l'appareil digestif, Lille, France

  https://orcid.org/0000-0001-9583-8946

  ⨯
• Petra Nytrova,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

  ⨯
• Christophe Richez,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Rheumatology Department, CHU de Bordeaux-GH Pellegrin, Bordeaux, France, UMR CNRS 5164, Bordeaux University, Bordeaux, France

  ⨯
• Malin Ryner,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

  ⨯
• Finn Sellebjerg,

  Roles Investigation, Writing – review & editing

  Affiliation Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

  ⨯
• Claudia Sievers,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland

  ⨯
• Dan Sikkema,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliations GlaxoSmithKline, Clinical Immunology–Biopharm, Collegeville, Pennsylvania, United States of America, Current address: Quanterix Corporation, Billerica, Massachusetts, United States of America

  ⨯
• Martin Soubrier,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Rheumatology, University Hospital of Clermont Ferrand, Clermont Ferrand, France

  https://orcid.org/0000-0001-9349-0720

  ⨯
• Sophie Tourdot,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation INSERM UMR 996, Faculty of Pharmacy, Paris-Sud University, Paris-Saclay University, Châtenay-Malabry, France

  ⨯
• Caroline Trang,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations GETAID, Paris, France, Institut des maladies de l'Appareil Digestif, University Hospital of Nantes, Nantes, France

  https://orcid.org/0000-0001-9140-5844

  ⨯
• Alessandra Vultaggio,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Dipartimento di Medicina Sperimentale e Clínica, Università di Firenze, Firenze, Italy

  ⨯
• Clemens Warnke,

  Roles Investigation, Writing – review & editing

  Affiliations University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany, Department of Neurology, University Hospital Köln, Köln, Germany

  https://orcid.org/0000-0002-3510-9255

  ⨯
• Sebastian Spindeldreher,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliations Drug Metabolism Pharmacokinetics-Biologics, Novartis Institutes for Biomedical Research, Basel, Switzerland, Integrated Biologix GmbH, Basel, Switzerland

  https://orcid.org/0000-0003-4682-9538

  ⨯
• Pierre Dönnes,

  Roles Conceptualization, Data curation, Project administration, Writing – review & editing

  Affiliation SciCross AB, Skövde, Sweden

  https://orcid.org/0000-0002-4613-2952

  ⨯
• Timothy P. Hickling,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation BioMedicine Design, Pfizer, Inc., Andover, Massachusetts, United States of America

  ⨯
• Agnès Hincelin Mery,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation Sanofi, Chilly-Mazarin, France

  ⨯
• Matthieu Allez,

  Roles Conceptualization, Project administration, Resources, Writing – review & editing

  Affiliations GETAID, Paris, France, Department of Gastroenterology, Hôpital Saint-Louis, AP-HP, Université Paris-Diderot, Paris, France

  https://orcid.org/0000-0002-2012-7522

  ⨯
• Florian Deisenhammer,

  Roles Conceptualization, Project administration, Resources, Writing – review & editing

  Affiliation Innsbruck Medical University, Department of Neurology, Innsbruck, Austria

  https://orcid.org/0000-0003-4541-8841

  ⨯
• Anna Fogdell-Hahn,

  Roles Conceptualization, Project administration, Resources, Writing – review & editing

  Affiliation Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

  https://orcid.org/0000-0002-0311-9184

  ⨯
• Xavier Mariette,

  Roles Conceptualization, Project administration, Resources, Writing – review & editing

  Affiliation Centre for Immunology of Viral Infections and Autoimmune Diseases, INSERM UMR 1184, Université Paris-Saclay, AP-HP.Université Paris-Saclay, Le Kremlin-Bicêtre, France

  https://orcid.org/0000-0002-4244-5417

  ⨯
• Marc Pallardy,

  Roles Conceptualization, Investigation, Project administration, Writing – review & editing

  Affiliation INSERM UMR 996, Faculty of Pharmacy, Paris-Sud University, Paris-Saclay University, Châtenay-Malabry, France

  ⨯
• Philippe Broët ,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Visualization, Writing – original draft

  * E-mail: signe.hassler@sorbonne-universite.fr (SH); philippe.broet@inserm.fr (PB)

  Affiliations CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, UVSQ, Paris-Saclay University, Villejuif, France, CHU Ste-Justine Research Center, Montreal, Canada, AP-HP, Paris-Sud University Hospitals, Paul Brousse Hospital, Villejuif, France

  https://orcid.org/0000-0001-9122-2810

  ⨯
•  [ ... ],
• ABIRISK consortium

  ¶Membership of the ABIRISK consortium is provided in the Acknowledgments.

  ⨯
• [ view all ]
• [ view less ]