Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials

• Samuel A. Danziger ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  * E-mail: sam.danziger@bms.com (SAD); alexander.ratushnyy@bms.com (AVR); gareth.morgan@nyulangone.org (GJM)

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-5669-414X

  ⨯
• Mark McConnell,

  Roles Data curation, Methodology, Software, Writing – review & editing

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-0978-2291

  ⨯
• Jake Gockley,

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Sage Bionetworks, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-7993-5308

  ⨯
• Mary H. Young,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Sage Bionetworks, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-2921-6107

  ⨯
• Adam Rosenthal,

  Roles Formal analysis, Writing – review & editing

  Affiliation Cancer Research and Biostatistics, Seattle, Washington, United States of America

  ⨯
• Frank Schmitz,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Sage Bionetworks, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-9090-0277

  ⨯
• David J. Reiss,

  Roles Formal analysis, Writing – review & editing

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  ⨯
• Phil Farmer,

  Roles Data curation, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0003-1448-1346

  ⨯
• Daisy V. Alapat,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  ⨯
• Amrit Singh,

  Roles Investigation, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0003-0566-3607

  ⨯
• Cody Ashby,

  Roles Conceptualization, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0002-9361-0283

  ⨯
• Michael Bauer,

  Roles Formal analysis, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0003-2498-7295

  ⨯
• Yan Ren,

  Roles Formal analysis, Writing – review & editing

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  ⨯
• Kelsie Smith,

  Roles Investigation, Writing – review & editing

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-4843-8645

  ⨯
• Suzana S. Couto,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Genmab, Princeton, New Jersey, United States

  ⨯
• Frits van Rhee,

  Roles Investigation, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0001-9959-1282

  ⨯
• Faith Davies,

  Roles Investigation, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  ⨯
• Maurizio Zangari,

  Roles Investigation, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  ⨯
• Nathan Petty,

  Roles Project administration, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  ⨯
• Robert Z. Orlowski,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

  ⨯
• Madhav V. Dhodapkar,

  Roles Validation, Writing – review & editing

  Affiliation Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Wilbert B. Copeland,

  Roles Conceptualization, Formal analysis, Writing – review & editing

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-9616-6341

  ⨯
• Brian Fox,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  ⨯
• Antje Hoering,

  Roles Formal analysis, Writing – review & editing

  Affiliation Cancer Research and Biostatistics, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-4709-3027

  ⨯
• Alison Fitch,

  Roles Project administration, Writing – review & editing

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  ⨯
• Katie Newhall,

  Roles Conceptualization, Writing – review & editing

  Affiliation Sage Bionetworks, Seattle, Washington, United States of America

  ⨯
• Bart Barlogie,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  https://orcid.org/0000-0001-6116-1017

  ⨯
• Matthew W. B. Trotter,

  Roles Methodology, Validation, Writing – review & editing

  Affiliation BMS Center for Innovation and Translational Research Europe (CITRE), Seville, Spain

  ⨯
• Robert M. Hershberg,

  Roles Conceptualization, Writing – review & editing

  Affiliation Sage Bionetworks, Seattle, Washington, United States of America

  ⨯
• Brian A. Walker,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0002-8615-6254

  ⨯
• Andrew P. Dervan,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation Sage Bionetworks, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-6482-8654

  ⨯
• Alexander V. Ratushny ,

  Contributed equally to this work with: Alexander V. Ratushny, Gareth J. Morgan

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  * E-mail: sam.danziger@bms.com (SAD); alexander.ratushnyy@bms.com (AVR); gareth.morgan@nyulangone.org (GJM)

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Bristol Myers Squibb, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-1701-4084

  ⨯
•  [ ... ],
• Gareth J. Morgan

  Contributed equally to this work with: Alexander V. Ratushny, Gareth J. Morgan

  Roles Conceptualization, Formal analysis, Investigation, Validation, Writing – original draft, Writing – review & editing

  * E-mail: sam.danziger@bms.com (SAD); alexander.ratushnyy@bms.com (AVR); gareth.morgan@nyulangone.org (GJM)

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  https://orcid.org/0000-0002-4271-6360

  ⨯
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