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Open Access
Peer-reviewed
Research Article
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
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Adam Penn-Nicholson ,
Contributed equally to this work with: Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson
Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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Thomas Hraha ,
Contributed equally to this work with: Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America
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Ethan G. Thompson ,
Contributed equally to this work with: Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation Center for Infectious Disease Research, Seattle, Washington, United States of America
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David Sterling,
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America
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Stanley Kimbung Mbandi,
Roles Data curation, Formal analysis, Methodology, Writing – review & editing
Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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Kirsten M. Wall,
Roles Data curation, Methodology, Project administration, Writing – review & editing
Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America
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Michelle Fisher,
Roles Investigation, Project administration, Writing – review & editing
Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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Sara Suliman,
Roles Data curation, Project administration, Writing – review & editing
Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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Smitha Shankar,
Roles Formal analysis, Writing – review & editing
Affiliation Center for Infectious Disease Research, Seattle, Washington, United States of America
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Willem A. Hanekom,
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing
Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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Nebojsa Janjic,
Roles Formal analysis, Project administration, Writing – review & editing
Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America
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Mark Hatherill,
Roles Funding acquisition, Investigation, Supervision, Writing – review & editing
Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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Stefan H. E. Kaufmann,
Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing
Affiliation Max Planck Institute for Infection Biology, Berlin, Germany
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Jayne Sutherland,
Roles Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing
Affiliation Medical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia
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Gerhard Walzl,
Roles Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing
Affiliation DST-NRF Centre of Excellence for Biomedical TB Research and MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
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Mary Ann De Groote,
Roles Formal analysis, Supervision, Writing – original draft, Writing – review & editing
Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America
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Urs Ochsner,
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – review & editing
Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America
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Daniel E. Zak,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – review & editing
Affiliation Center for Infectious Disease Research, Seattle, Washington, United States of America
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Thomas J. Scriba ,
Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: thomas.scriba@uct.ac.za
Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
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ACS and GC6–74 cohort study groups
¶Membership of the ACS and GC6–74 cohort study groups is provided in
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Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
- Adam Penn-Nicholson,
- Thomas Hraha,
- Ethan G. Thompson,
- David Sterling,
- Stanley Kimbung Mbandi,
- Kirsten M. Wall,
- Michelle Fisher,
- Sara Suliman,
- Smitha Shankar,
- Willem A. Hanekom
- Published: April 16, 2019
- https://doi.org/10.1371/journal.pmed.1002781