Tuberculosis drugs’ distribution and emergence of resistance in patient’s lung lesions: A mechanistic model and tool for regimen and dose optimization

• Natasha Strydom,

  Roles Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

  http://orcid.org/0000-0002-0929-0783

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• Sneha V. Gupta,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

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• William S. Fox,

  Roles Software, Writing – review & editing

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

  http://orcid.org/0000-0002-4058-4333

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• Laura E. Via,

  Roles Investigation, Writing – review & editing

  Affiliation Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America

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• Hyeeun Bang,

  Roles Investigation, Writing – review & editing

  Affiliation Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America

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• Myungsun Lee,

  Roles Data curation, Writing – review & editing

  Affiliation International Tuberculosis Research Center, Changwon, Republic of Korea

  http://orcid.org/0000-0002-8170-1807

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• Seokyong Eum,

  Roles Data curation, Writing – review & editing

  Affiliation International Tuberculosis Research Center, Changwon, Republic of Korea

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• TaeSun Shim,

  Roles Data curation, Writing – review & editing

  Affiliation Asan Medical Center, Seoul, Republic of Korea

  http://orcid.org/0000-0001-6653-816X

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• Clifton E. Barry III,

  Roles Investigation, Writing – review & editing

  Affiliation Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, Maryland, United States of America

  http://orcid.org/0000-0002-2927-270X

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• Matthew Zimmerman,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Public Health Research Institute and New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, United States of America

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• Véronique Dartois,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Writing – review & editing

  Affiliation Public Health Research Institute and New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, United States of America

  http://orcid.org/0000-0001-9470-5009

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• Radojka M. Savic

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: rada.savic@ucsf.edu

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America

  http://orcid.org/0000-0003-3143-5579

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