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Open Access
Peer-reviewed
Research Article
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
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Miriam S. Udler,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing
Affiliations Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Jaegil Kim,
Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing
Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Marcin von Grotthuss,
Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing
Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Sílvia Bonàs-Guarch,
Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona, Spain
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Joanne B. Cole,
Roles Data curation, Writing – original draft, Writing – review & editing
Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Joshua Chiou,
Roles Formal analysis, Writing – original draft, Writing – review & editing
Affiliation Department of Pediatrics, University of California San Diego, San Diego, California, United States of America
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Christopher D. Anderson on behalf of METASTROKE and the ISGC,
Roles Conceptualization, Writing – original draft, Writing – review & editing
Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Michael Boehnke,
Roles Data curation, Validation, Writing – review & editing
Affiliation Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
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Markku Laakso,
Roles Data curation, Validation, Writing – review & editing
Affiliation Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
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Gil Atzmon,
Roles Data curation, Validation, Writing – review & editing
Affiliations Faculty of Natural Sciences, University of Haifa, Haifa, Israel, Department of Medicine; Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Genetics, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America
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Benjamin Glaser,
Roles Data curation, Validation, Writing – review & editing
Affiliation Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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Josep M. Mercader,
Roles Data curation, Supervision, Writing – original draft, Writing – review & editing
Affiliations Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Barcelona Supercomputing Center (BSC), Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona, Spain
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Kyle Gaulton,
Roles Formal analysis, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Pediatrics, University of California San Diego, San Diego, California, United States of America
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Jason Flannick,
Roles Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing
Affiliations Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Genetics, Boston Children’s Hospital, Boston, Massachusetts, United States of America
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Gad Getz,
Roles Conceptualization, Methodology, Supervision, Writing – review & editing
Affiliation Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
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Jose C. Florez
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: jcflorez@mgh.harvard.edu
Affiliations Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis
- Miriam S. Udler,
- Jaegil Kim,
- Marcin von Grotthuss,
- Sílvia Bonàs-Guarch,
- Joanne B. Cole,
- Joshua Chiou,
- Christopher D. Anderson on behalf of METASTROKE and the ISGC,
- Michael Boehnke,
- Markku Laakso,
- Gil Atzmon
- Published: September 21, 2018
- https://doi.org/10.1371/journal.pmed.1002654