Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

Rebecca C. Richmond; Nicholas J. Timpson; Janine F. Felix; Tom Palmer; Romy Gaillard; George McMahon; George Davey Smith; Vincent W. Jaddoe; Debbie A. Lawlor

doi:10.1371/journal.pmed.1002221

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Open Access

Peer-reviewed

Research Article

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

Rebecca C. Richmond ,

* E-mail: rebecca.richmond@bristol.ac.uk

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

http://orcid.org/0000-0003-0574-5071

⨯
Nicholas J. Timpson,

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

http://orcid.org/0000-0002-7141-9189

⨯
Janine F. Felix,

Affiliations The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
⨯
Tom Palmer,

Affiliation Department of Mathematics and Statistics, Lancaster University, Lancaster, United Kingdom
⨯
Romy Gaillard,

Affiliations The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
⨯
George McMahon,

Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
George Davey Smith,

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

http://orcid.org/0000-0002-1407-8314

⨯
Vincent W. Jaddoe,

Affiliations The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

http://orcid.org/0000-0003-2939-0041

⨯
Debbie A. Lawlor

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

http://orcid.org/0000-0002-6793-2262

⨯

Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study

Rebecca C. Richmond,
Nicholas J. Timpson,
Janine F. Felix,
Tom Palmer,
Romy Gaillard,
George McMahon,
George Davey Smith,
Vincent W. Jaddoe,
Debbie A. Lawlor

Published: January 24, 2017
https://doi.org/10.1371/journal.pmed.1002221

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Pregnancy
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Body weight
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Genetics
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Adipose tissue
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Single nucleotide polymorphisms
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