Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

Christine A. Parkinson; Davina Gale; Anna M. Piskorz; Heather Biggs; Charlotte Hodgkin; Helen Addley; Sue Freeman; Penelope Moyle; Evis Sala; Karen Sayal; Karen Hosking; Ioannis Gounaris; Mercedes Jimenez-Linan; Helena M. Earl; Wendi Qian; Nitzan Rosenfeld; James D. Brenton

doi:10.1371/journal.pmed.1002198

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Research Article

Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

Christine A. Parkinson ,

Contributed equally to this work with: Christine A. Parkinson, Davina Gale

Affiliations Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Davina Gale ,

Contributed equally to this work with: Christine A. Parkinson, Davina Gale

Affiliations Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Anna M. Piskorz,

Affiliations Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Heather Biggs,

Affiliations Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Charlotte Hodgkin,

Affiliations Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Helen Addley,

Affiliations Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Sue Freeman,

Affiliations Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Penelope Moyle,

Affiliations Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Evis Sala,

Current address: Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

Affiliation Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom
⨯
Karen Sayal,

Affiliation Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom
⨯
Karen Hosking,

Affiliations Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Ioannis Gounaris,

Affiliations Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Mercedes Jimenez-Linan,

Affiliations Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom

http://orcid.org/0000-0002-8164-5462

⨯
Helena M. Earl,

Affiliations Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
Wendi Qian,

Affiliations Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom

http://orcid.org/0000-0002-4238-3471

⨯
Nitzan Rosenfeld ,

* E-mail: Nitzan.Rosenfeld@cruk.cam.ac.uk (NR); James.Brenton@cruk.cam.ac.uk (JDB)

Affiliations Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
[ ... ],
James D. Brenton

* E-mail: Nitzan.Rosenfeld@cruk.cam.ac.uk (NR); James.Brenton@cruk.cam.ac.uk (JDB)

Affiliations Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom, NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, Cancer Research UK Major Centre–Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom
⨯
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Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

Christine A. Parkinson,
Davina Gale,
Anna M. Piskorz,
Heather Biggs,
Charlotte Hodgkin,
Helen Addley,
Sue Freeman,
Penelope Moyle,
Evis Sala,
Karen Sayal

Published: December 20, 2016
https://doi.org/10.1371/journal.pmed.1002198

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Circulating tumor DNA
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