Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

• Luca A. Lotta,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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• Robert A. Scott,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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• Stephen J. Sharp,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

  http://orcid.org/0000-0003-2375-1440

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• Stephen Burgess,

  Affiliation Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  http://orcid.org/0000-0001-5365-8760

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• Jian’an Luan,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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• Therese Tillin,

  Affiliation Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom

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• Amand F. Schmidt,

  Affiliation Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom

  http://orcid.org/0000-0003-1327-0424

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• Fumiaki Imamura,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

  http://orcid.org/0000-0002-6841-8396

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• Isobel D. Stewart,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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• John R. B. Perry,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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• Luke Marney,

  Affiliation MRC Human Nutrition Research, Cambridge, United Kingdom

  http://orcid.org/0000-0001-8117-8246

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• Albert Koulman,

  Affiliation MRC Human Nutrition Research, Cambridge, United Kingdom

  http://orcid.org/0000-0001-9998-051X

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• Edward D. Karoly,

  Affiliation Metabolon, Morrisville, North Carolina, United States of America

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• Nita G. Forouhi,

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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• Rasmus J. O. Sjögren,

  Affiliation Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-0640-8504

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• Erik Näslund,

  Affiliation Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-0166-6344

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• Juleen R. Zierath,

  Affiliations Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

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• Anna Krook,

  Affiliation Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

  http://orcid.org/0000-0002-0891-0258

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• David B. Savage,

  Affiliation Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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• Julian L. Griffin,

  Affiliations MRC Human Nutrition Research, Cambridge, United Kingdom, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

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• Nishi Chaturvedi,

  Affiliation Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom

  http://orcid.org/0000-0002-6211-2775

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• Aroon D. Hingorani,

  Affiliation Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, United Kingdom

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• Kay-Tee Khaw,

  Affiliation Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

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• Inês Barroso,

  Affiliations Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

  http://orcid.org/0000-0001-5800-4520

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• Mark I. McCarthy,

  Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0002-4393-0510

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• Stephen O’Rahilly,

  Affiliation Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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• Nicholas J. Wareham ,

  * E-mail: Nick.Wareham@mrc-epid.cam.ac.uk (NJW); Claudia.Langenberg@mrc-epid.cam.ac.uk (CL)

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

  http://orcid.org/0000-0003-1422-2993

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•  [ ... ],
• Claudia Langenberg

  * E-mail: Nick.Wareham@mrc-epid.cam.ac.uk (NJW); Claudia.Langenberg@mrc-epid.cam.ac.uk (CL)

  Affiliation MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

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