Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

• Søren D. Østergaard,

  Affiliations Research Department P, Aarhus University Hospital, Risskov, Denmark, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

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• Shubhabrata Mukherjee,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Stephen J. Sharp,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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• Petroula Proitsi,

  Affiliation Department of Basic and Clinical Neuroscience, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom

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• Luca A. Lotta,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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• Felix Day,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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• John R. B. Perry,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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• Kevin L. Boehme,

  Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

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• Stefan Walter,

  Affiliation Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, California, United States of America

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• John S. Kauwe,

  Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

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• Laura E. Gibbons,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Alzheimer’s Disease Genetics Consortium ,

  ¶Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in S1 Text. Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report.

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• The GERAD1 Consortium ,

  ¶Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in S1 Text. Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report.

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• EPIC-InterAct Consortium ,

  ¶Membership of the Alzheimer’s Disease Genetics Consortium, the Genetic and Environmental Risk in AD (GERAD1) Consortium, and the EPIC-InterAct Consortium is provided in S1 Text. Data used in the preparation of this article were obtained from GERAD1. As such, the investigators within GERAD1 contributed to the design and implementation of GERAD1 and/or provided data but did not participate in the analysis or writing of this report.

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• Eric B. Larson,

  Affiliations Department of Medicine, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Seattle, Washington, United States of America

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• John F. Powell,

  Affiliation Department of Basic and Clinical Neuroscience, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom

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• Claudia Langenberg,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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• Paul K. Crane,

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

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• Nicholas J. Wareham,

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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•  [ ... ],
• Robert A. Scott

  * E-mail: Robert.Scott@mrc-epid.cam.ac.uk

  Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom

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