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Open Access
Peer-reviewed
Research Article
Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies
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Cari M. Kitahara ,
* E-mail: kitaharac@mail.nih.gov
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Alan J. Flint,
Affiliations Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Amy Berrington de Gonzalez,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Leslie Bernstein,
Affiliation Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, California, United States of America
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Michelle Brotzman,
Affiliation Westat, Rockville, Maryland, United States of America
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Robert J. MacInnis,
Affiliations Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia, Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
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Steven C. Moore,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Kim Robien,
Affiliation Department of Epidemiology and Biostatistics, School of Public Health and Health Services, George Washington University, Washington, District of Columbia, United States of America
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Philip S. Rosenberg,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Pramil N. Singh,
Affiliation Center for Health Research, School of Public Health, Loma Linda University, Loma Linda, California, United States of America
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Elisabete Weiderpass,
Affiliations Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Community Medicine, Faculty of Health Sciences, University of Tromsø—The Arctic University of Norway, Tromsø, Norway, Department of Research, Cancer Registry of Norway, Oslo, Norway, Samfundet Folkhälsan, Helsinki, Finland
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Hans Olov Adami,
Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Hoda Anton-Culver,
Affiliation Department of Epidemiology, School of Medicine, University of California, Irvine, California, United States of America
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Rachel Ballard-Barbash,
Affiliation Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, United States of America
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Julie E. Buring,
Affiliation Divisions of Preventive Medicine and Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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D. Michal Freedman,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Gary E. Fraser,
Affiliation Department of Epidemiology, Biostatistics, and Population Medicine, Loma Linda University School of Public Health, Loma Linda, California, United States of America
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Laura E. Beane Freeman,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Susan M. Gapstur,
Affiliation Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America
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John Michael Gaziano,
Affiliations Divisions of Preventive Medicine and Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, Massachusetts, United States of America
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Graham G. Giles,
Affiliations Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Australia, Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
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Niclas Håkansson,
Affiliation Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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Jane A. Hoppin,
Affiliation Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, United States of America
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Frank B. Hu,
Affiliations Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
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Karen Koenig,
Affiliation Division of Epidemiology, Department of Population Health and NYU Cancer Institute, NYU School of Medicine, New York, New York, United States of America
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Martha S. Linet,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Yikyung Park,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Alpa V. Patel,
Affiliation Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America
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Mark P. Purdue,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Catherine Schairer,
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Howard D. Sesso,
Affiliation Divisions of Preventive Medicine and Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Kala Visvanathan,
Affiliations Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States of America, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
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Emily White,
Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Alicja Wolk,
Affiliation Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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Anne Zeleniuch-Jacquotte,
Affiliation Division of Epidemiology, Department of Population Health and NYU Cancer Institute, NYU School of Medicine, New York, New York, United States of America
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Patricia Hartge
Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
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Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies
- Cari M. Kitahara,
- Alan J. Flint,
- Amy Berrington de Gonzalez,
- Leslie Bernstein,
- Michelle Brotzman,
- Robert J. MacInnis,
- Steven C. Moore,
- Kim Robien,
- Philip S. Rosenberg,
- Pramil N. Singh
- Published: July 8, 2014
- https://doi.org/10.1371/journal.pmed.1001673