https://orcid.org/0000-0001-6657-5665
Reader Comments
Post a new comment on this article
Post Your Discussion Comment
Please follow our guidelines for comments and review our competing interests policy. Comments that do not conform to our guidelines will be promptly removed and the user account disabled. The following must be avoided:
- Remarks that could be interpreted as allegations of misconduct
- Unsupported assertions or statements
- Inflammatory or insulting language
Thank You!
Thank you for taking the time to flag this posting; we review flagged postings on a regular basis.
closeRE: Lipids and atrial fibrillation: New insights into a paradox
Posted by DrRajivKumarGmchChandigarhIndia on 23 Aug 2022 at 11:04 GMT
It is good to read perspective on the very important topic "Lipids and Atrial Fibrillation: New Insights in a Paradox".
I appreciate the authors for their research and for a good compilation.
Dyslipidemia is a known risk factor for cardiovascular diseases, but the paradoxical inverse relationship between lipid levels and atrial fibrillation as reported by the authors is provocative and an eye-opener.
The authors rightly mentiond that until the understanding of the pathophysiology behind this paradoxical observation is improved, "hyperlipidemia should be assessed as part of overall cardiovascular risk, and atrial fibrillation paradox should not outweigh this risk".
Regards,
Dr.Rajiv Kumar
Faculty, Department of Pharmacology,
Government Medical College and Hospital Chandigarh-160030, India.
RE: RE: Lipids and atrial fibrillation: New insights into a paradox
DrRajivKumarGmchChandigarhIndia replied to DrRajivKumarGmchChandigarhIndia on 24 Aug 2022 at 05:24 GMT
Cholesterol performs functions that are Good for Health.
Cholesterol is a precursor molecule for the synthesis of steroid hormones (cortisol & aldosterone), sex hormones (progesterone, estrogen, & testosterone) and for the making of Vitamin D Cholesterol maintains cell membranes, nerve myelin sheath and improve immune functions [1]. High cholesterol protects against infection [2], while low cholesterol predicted an increased risk of dying from gastrointestinal and respiratory diseases [3] and associated with risk of death from AIDS [4].
This observational evidence is very important for health care system and will benefits the patients from unnecessary use of "lipid lowering agents".
References:
1.Hanukoglu I . "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis.". J Steroid Biochem Mol Biol. Dec1992 43 (8): 779–804.doi:10.1016/0960-0760(92)90307-5
2.Ravnskov U. High cholesterol may protect against infections and atherosclerosis. Quarterly Journal of Medicine 96, 927-934, 2003.
3.Jacobs D and others. Report of the conference on low blood cholesterol: Mortality associations. Circulation 86, 1046–1060, 1992.
4.Neaton JD, Wentworth DN. Low serum cholesterol and risk of death from AIDS. AIDS 11, 929–930, 1997.
.