About the Authors

Wei Zhou

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration

‡ These authors share first authorship on this work.

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Wanbing Feng

Roles Data curation, Writing – original draft

‡ These authors share first authorship on this work.

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Jinli Chang

Roles Writing – review & editing

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Jingmei Hu

Roles Formal analysis, Validation, Writing – review & editing

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Fuxia Li

Roles Formal analysis, Investigation, Software

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Kuona Hu

Roles Supervision, Validation, Writing – review & editing

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Jiejing Jiao

Roles Investigation, Validation, Writing – review & editing

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Xinyi Xue

Roles Investigation, Validation, Writing – review & editing

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Ting Lan

Roles Investigation, Validation

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Wenjing Wan

Roles Validation, Visualization, Writing – review & editing

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Zi-Jiang Chen

Roles Conceptualization, Project administration, Resources, Supervision

chenzijiang@hotmail.com (Z-JC); fdclear3@126.com (LC)

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China, Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Linlin Cui

Roles Funding acquisition, Resources, Supervision, Writing – original draft

chenzijiang@hotmail.com (Z-JC); fdclear3@126.com (LC)

Affiliations State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, the Second Hospital, Shandong University, Jinan, Shandong, China, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China, Key laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, China, Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, China, Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, China, Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China

Competing Interests

The authors have declared that no competing interests exist.