About the Authors

Chris C. Parker

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

chris.parker@icr.ac.uk (CCP); m.sydes@ucl.ac.uk (MRS)

Affiliation The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom

Nicholas D. James

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom

Christopher D. Brawley

Roles Data curation, Formal analysis, Investigation, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Noel W. Clarke

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations The Christie Hospital, Manchester, United Kingdom, Salford Royal Hospitals, Manchester, United Kingdom

Adnan Ali

Roles Data curation, Investigation, Project administration, Validation, Writing – review & editing

Affiliation The Christie Hospital, Manchester, United Kingdom

Claire L. Amos

Roles Data curation, Investigation, Project administration, Supervision, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Gerhardt Attard

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation UCL Cancer Institute, UCL, London, United Kingdom

Simon Chowdhury

Roles Data curation, Supervision, Writing – review & editing

Affiliation Guys and St Thomas’s NHS Foundation Trust, London, United Kingdom

Adrian Cook

Roles Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

William Cross

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation St James’s University Hospital, Leeds, United Kingdom

David P. Dearnaley

Roles Data curation, Funding acquisition, Investigation, Supervision, Writing – review & editing

Affiliation The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom

Hassan Douis

Roles Investigation

Affiliation University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

Duncan C. Gilbert

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Clare Gilson

Roles Data curation, Investigation, Project administration, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Silke Gillessen

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliations Istituto Oncologico della Svizzera Italiana, EOC, Bellinzona, Switzerland, Università della Svizzera Italiana, Lugano, Switzerland

Alex Hoyle

Roles Data curation, Investigation, Project administration, Validation, Writing – review & editing

Affiliations The Christie Hospital, Manchester, United Kingdom, Salford Royal Hospitals, Manchester, United Kingdom

Rob J. Jones

Roles Data curation, Investigation, Supervision

Affiliation Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

Ruth E. Langley

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Zafar I. Malik

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation Clatterbridge Cancer Centre, Liverpool, United Kingdom

Malcolm D. Mason

Roles Data curation, Funding acquisition, Investigation, Methodology, Writing – review & editing

Affiliation Cardiff University, Cardiff, United Kingdom

David Matheson

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation University of Wolverhampton, Wolverhampton, United Kingdom

Robin Millman

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Mary Rauchenberger

Roles Data curation, Investigation, Software, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Hannah Rush

Roles Data curation, Investigation, Project administration, Writing – review & editing

Affiliations MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom, Guys and St Thomas’s NHS Foundation Trust, London, United Kingdom

J Martin Russell

Roles Data curation, Investigation, Supervision, Writing – review & editing

Affiliation Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

Hannah Sweeney

Roles Data curation, Investigation, Project administration, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Amit Bahl

Roles Data curation, Investigation, Writing – review & editing

Affiliation University Hospitals Bristol NHS Trust, Bristol, United Kingdom

Alison Birtle

Roles Data curation, Investigation, Writing – review & editing

Affiliations Rosemere Cancer Centre, Lancs Teaching Hospitals, University of Manchester, Manchester, United Kingdom, UCLan, Lanchashire, United Kingdom

Lisa Capaldi

Roles Data curation, Investigation, Writing – review & editing

Affiliation Worcestershire Acute Hospitals NHS Trust, Worcester, United Kingdom

Omar Din

Roles Data curation, Investigation, Writing – review & editing

Affiliation Weston Park Cancer Centre, Sheffield, United Kingdom

Daniel Ford

Roles Data curation, Investigation, Writing – review & editing

Affiliation University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

Joanna Gale

Roles Data curation, Investigation, Writing – review & editing

Affiliation Queen Alexandra Hospital, Portsmouth, United Kingdom

Ann Henry

Roles Data curation, Investigation, Writing – review & editing

Affiliation University of Leeds, Leeds, United Kingdom

Peter Hoskin

Roles Data curation, Investigation, Writing – review & editing

Affiliations The Christie Hospital, Manchester, United Kingdom, Mount Vernon Cancer Centre, Northwood, United Kingdom

Mohammed Kagzi

Roles Data curation, Investigation, Writing – review & editing

Affiliation The James Cook University Hospital, Middlesbrough, United Kingdom

Anna Lydon

Roles Data curation, Investigation, Writing – review & editing

Affiliation Torbay and South Devon NHS Trust, Torbay, United Kingdom

Joe M. O’Sullivan

Roles Data curation, Investigation, Writing – review & editing

Affiliation Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, United Kingdom

Sangeeta A. Paisey

Roles Data curation, Investigation, Writing – review & editing

Affiliation Hampshire Hospitals NHS Foundation Trust, Hampshire, United Kingdom

Omi Parikh

Roles Data curation, Investigation, Writing – review & editing

Affiliation Royal Preston Hospital, Preston, United Kingdom

Delia Pudney

Roles Data curation, Investigation, Writing – review & editing

Affiliation South West Wales Cancer Centre, Swansea, United Kingdom

Vijay Ramani

Roles Data curation, Investigation, Writing – review & editing

Affiliations The Christie Hospital, Manchester, United Kingdom, Manchester University Hospitals NHS Trust, Manchester, United Kingdom

Peter Robson

Roles Conceptualization, Data curation, Investigation, Writing – review & editing

Affiliation Clatterbridge Cancer Centre, Liverpool, United Kingdom

Narayanan Nair Srihari

Roles Data curation, Investigation, Writing – review & editing

Affiliation Shrewsbury & Telford Hospitals NHS Trust, Shrewsbury, United Kingdom

Jacob Tanguay

Roles Data curation, Investigation, Writing – review & editing

Affiliation Velindre Cancer Centre, Cardiff, United Kingdom

Mahesh K. B. Parmar

Contributed equally to this work with: Mahesh K. B. Parmar, Matthew R. Sydes

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

Matthew R. Sydes

Contributed equally to this work with: Mahesh K. B. Parmar, Matthew R. Sydes

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

chris.parker@icr.ac.uk (CCP); m.sydes@ucl.ac.uk (MRS)

Affiliation MRC Clinical Trials Unit at UCL, UCL, London, United Kingdom

for the STAMPEDE Trial Collaborative Group

Membership of the STAMPEDE Trial Collaborative Group is listed in S4 Text.

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: CCP reports personal fees from Bayer, personal fees from Janssen, personal fees from Clarity Pharmaceuticals, personal fees from Myovant, personal fees from ITM Oncologics, outside the submitted work NDJ received research funding to the institution from Astellas, Astra Zeneca &Janssen; receipt of honoraria/fees on the advisory board for Astra Zenenca, Clovis, Janssen, Merck, Novartis & Sanofi; received fees as a speaker for Bayer & Novartis NWC received honoraria from Astellas & Janssen; took a consulting/advisory role for Astellas, Janssen, Ferring, Bayer & Sanofi; was paid speakers fees b Janssen & Astellas; received funding for the institution from Astra Zeneca; received meeting and travel expenses from Janssen, Astellas, Sanofi, Astra Zeneca, Ferring & Ipsen GA reports personal fees from Sanofi Aventis, during the conduct of the study; personal fees and non-financial support from Astellas, personal fees and non-financial support from Medivation, personal fees from Novartis, personal fees from Millennium Pharmaceuticals, personal fees and non-financial support from Abbott Laboratories, personal fees and non-financial support from Essa Pharmaceuticals, personal fees and non-financial support from Bayer Healthcare Pharmaceuticals, personal fees from Takeda, grants from AstraZeneca, grants from Arno Therapeutics, grants from Innocrin Pharma, grants, personal fees and non-financial support from Janssen, personal fees from Veridex, personal fees and non-financial support from Roche/Ventana, personal fees and non-financial support from Pfizer, personal fees from The Institute of Cancer Research (ICR), outside the submitted work; and The Institute of Cancer Research (ICR) receives royalty income from abiraterone I receive a share of this income through the ICR’s Rewards to Discoverers Scheme SC received consulting fees from Telix, remedy & Huma; received payment for speaker fees and/or manuscript writing and/or educational events from Astra Zeneca, Novartis/AAA, Clovis, Janssen, Bayer, Pfizer, Beigene & Astellas; they were a member of the data safety monitoring/advisory board for Astra Zeneca, Novartis/AAA, Clovis, Janssen, Bayer, Pfizer, Beigene & Astellas DPD received payment to the institution from C33589/A19727 Advances in Physics for Precision Radiotherapy; previous employer, The Institute of Cancer Research receives loyalty income from abiraterone, receives personal share of this income through ICR’s Rewards to Discoverer’s Scheme; honoraria for consultancy from Janssen; EP1933709B1 – Location and Stabilisation Device., European patent issued, Pending in Canada and India SG reports personal fees from Orion, personal fees from Janssen Cilag, personal fees from ProteoMedix, personal fees from Amgen, personal fees from MSD, other from Tolero Pharmaceuticals, other from Astellas Pharma, other from Janssen, other from MSD Merck Sharp&Dome, other from Bayer, other from Roche, other from Pfizer, other from Telixpharma, other from Amgen, other from Bristol-Myers Squibb, other from AAA International SA, other from Orion, other from Silvio Grasso Consulting, from Tolremo, outside the submitted work; In addition, Gillessen has a patent WO2009138392 issued and Menarini Silicon Biosystems (Advisory Board 2019) - not compensated Aranda (Advisory Board 2019) - not compensated RJJ received research funding to the institution from Bayer, Astellas & Pfizer; received honoraria on the advisory board for Janssen, Astellas, Bayer, Pfizer; received speaker fees from Janssen, Astellas, Bayer & Pfizer REL received an institutional grant from the MRC CG received research funding to the institution from Janssen, Clovis Oncology, Sanofi, Astellas, Medical Research Council & Cancer Research UK DF received speaker fees and/or manuscript writing and/or educational events from BMS, IPSEN, EUSA, Pfizer, ESAI; they received travel expenses from Janssen & IPSEN MDM is an advisory board member for Endocyte & Clovis AB received payment for lecture/presentation/speaker bureau/manuscript writing or educational event from Boston Scientific AJB received speaker fees and travel support from Janssen DF received payment for lectures for Janssen, Pfizer & BMS; support for attending conferences/meetings from Genisiscare & BMS AMH received research grants from CRUK and NIHR; support attending meetings from the European Association of Urologists; is a member of the European Association of Urologists & the Prostate Cancer Guidelines Group MK received travel, accommodation and conference fees as expenses from Bayer, travel and accommodation fees for Prostate cancer summits from Janssen AL received expenses for attending meetings and/or travel from Astellas, Bayer, BMS & MSD JMOS received speaker fees from AAA, Astellas, Bayer, Janssen, Novartis, Sanofi and participated as an advisory board member and/or member of the data safety monitoring board for AAA, Astellas, Bayer, Janssen, Novartis & Sanofi NNS received travel/meeting payments from Janssen JT received support for conference attendance from Janssen, Roche & Bayer; participated on the advisory board for Astra Zeneca, Astellas & Bayer MKBP received research funding to the Unit he directs from Acoria Pvt Ltd, Akagera, Amgen, Aspirin Foundation, Astellas, AstraZeneca, Baxter, Bayer, BMS US, Bri-Bio, Cepheid, Cipla, Clovis Inc, CSL Behring, Eli-Lilly, Emergent Biosolutions, Gilead Sciences, GlaxoSmithKline, Grifols, Janssen Products LP, Janssen-Cilag, Johnson & Johnson, Micronoma, Modus Theraputics, Mylan, Novartis, Pfizer, Sanofi, Serum Institute of India, Shionogi, Synteny Biotechnology, Takeda, Tibotec, Transgene, ViiV Healthcare, Virco and Xenothera MRS received research funding to the institution from Astellas, Clovis, Janssen, Novartis, Pfizer, Sanofi-Aventis; received speaker fees from Lilly Oncology & Janssen; independent member of data monitoring committees. All other authors have nothing to declare.