About the Authors

Michael Fralick

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

mif823@mail.harvard.edu

Affiliations Division of Pharmacoepidemiology and Pharmacoeconomics, Program On Regulation, Therapeutics, And Law (PORTAL), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Eliot Phillipson Clinician Scientist Training Program, Department of Medicine, University of Toronto, Toronto, Canada

Sebastian Schneeweiss

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Writing – review & editing

Affiliation Division of Pharmacoepidemiology and Pharmacoeconomics, Program On Regulation, Therapeutics, And Law (PORTAL), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Christopher J. D. Wallis

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliations Eliot Phillipson Clinician Scientist Training Program, Department of Medicine, University of Toronto, Toronto, Canada, Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario

Emily H. Jung

Roles Methodology, Project administration, Writing – review & editing

Affiliation Division of Pharmacoepidemiology and Pharmacoeconomics, Program On Regulation, Therapeutics, And Law (PORTAL), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Aaron S. Kesselheim

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Writing – review & editing

Affiliation Division of Pharmacoepidemiology and Pharmacoeconomics, Program On Regulation, Therapeutics, And Law (PORTAL), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: SS is the principal investigator of investigator-initiated grants to the Brigham and Women’s Hospital from Vertex, and Boehringer Ingelheim unrelated to the topic of this study. He is a consultant to WHISCON and to Aetion, a software manufacturer of which he owns equity. His interests were declared, reviewed, and approved by the Brigham and Women’s Hospital and Partners HealthCare System in accordance with their institutional compliance policies. AK is an Academic Editor on PLOS Medicine’s editorial board. SS, and AK are Faculty members at the Division of Pharmacoepidemiology and Pharmacoeconomics, which funded access to the data at the Optum database. MF, CW, and EH have declared that they do not have any competing interests.