Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Amita Gupta; Michael D. Hughes; Anthony J. Garcia-Prats; Katherine McIntire; Anneke C. Hesseling

doi:10.1371/journal.pmed.1002882

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Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Amita Gupta ,

* E-mail: agupta25@jhmi.edu

Affiliation Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

http://orcid.org/0000-0001-7036-2718

⨯
Michael D. Hughes,

Affiliation Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America
⨯
Anthony J. Garcia-Prats,

Affiliation Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

http://orcid.org/0000-0002-9280-1950

⨯
Katherine McIntire,

Affiliation Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

http://orcid.org/0000-0001-8884-3384

⨯
Anneke C. Hesseling

Affiliation Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa
⨯

Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons

Amita Gupta,
Michael D. Hughes,
Anthony J. Garcia-Prats,
Katherine McIntire,
Anneke C. Hesseling

Published: August 15, 2019
https://doi.org/10.1371/journal.pmed.1002882

About the Authors

Amita Gupta

* E-mail: agupta25@jhmi.edu

Affiliation Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

http://orcid.org/0000-0001-7036-2718

Michael D. Hughes

Affiliation Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America

Anthony J. Garcia-Prats

Affiliation Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

http://orcid.org/0000-0002-9280-1950

Katherine McIntire

Affiliation Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

http://orcid.org/0000-0001-8884-3384

Anneke C. Hesseling

Affiliation Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

Competing Interests

The authors have declared that no competing interests exist.

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Tuberculosis
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Pregnancy
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Drug research and development
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Infants
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HIV
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Medical risk factors
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Drug therapy
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Clinical trials
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