About the Authors

Adam Penn-Nicholson

Contributed equally to this work with: Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Thomas Hraha

Contributed equally to this work with: Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America

Ethan G. Thompson

Contributed equally to this work with: Adam Penn-Nicholson, Thomas Hraha, Ethan G. Thompson

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Center for Infectious Disease Research, Seattle, Washington, United States of America

David Sterling

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America

Stanley Kimbung Mbandi

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Kirsten M. Wall

Roles Data curation, Methodology, Project administration, Writing – review & editing

Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America

Michelle Fisher

Roles Investigation, Project administration, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Sara Suliman

Roles Data curation, Project administration, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Smitha Shankar

Roles Formal analysis, Writing – review & editing

Affiliation Center for Infectious Disease Research, Seattle, Washington, United States of America

Willem A. Hanekom

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Nebojsa Janjic

Roles Formal analysis, Project administration, Writing – review & editing

Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America

Mark Hatherill

Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

Stefan H. E. Kaufmann

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Max Planck Institute for Infection Biology, Berlin, Germany

Jayne Sutherland

Roles Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Medical Research Council Unit, The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia

Gerhard Walzl

Roles Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation DST-NRF Centre of Excellence for Biomedical TB Research and MRC Centre for TB Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

Mary Ann De Groote

Roles Formal analysis, Supervision, Writing – original draft, Writing – review & editing

Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America

Urs Ochsner

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – review & editing

Affiliation SomaLogic, Inc., Boulder, Colorado, United States of America

Daniel E. Zak

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

Affiliation Center for Infectious Disease Research, Seattle, Washington, United States of America

Thomas J. Scriba

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

thomas.scriba@uct.ac.za

Affiliation South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

ACS and GC6–74 cohort study groups

Membership of the ACS and GC6–74 cohort study groups is provided in S1 Text.

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: TH, DS, NJ, MAD, DS, and UO are employees and shareholders of SomaLogic. KW is a shareholder in SomaLogic. APN, TH, ET, NJ, UO, DZ, and TJS are co-inventors on patents of the proteomic signatures. MH served as Guest Editor on PLOS Medicine’s Special Issue on New Tools and Strategies for Tuberculosis Diagnosis, Care, and Elimination.​