About the Authors

Alastair J. Noyce

Contributed equally to this work with: Alastair J. Noyce, Demis A. Kia

Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom, Centre for Neuroscience and Trauma, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Demis A. Kia

Contributed equally to this work with: Alastair J. Noyce, Demis A. Kia

Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

Gibran Hemani

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

Aude Nicolas

Affiliation Laboratory for Neurogenetics, National Institute on Aging National Institutes of Health, Bethesda, Maryland, United States of America

T. Ryan Price

Affiliation Laboratory for Neurogenetics, National Institute on Aging National Institutes of Health, Bethesda, Maryland, United States of America

Eduardo De Pablo-Fernandez

Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

Philip C. Haycock

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

Patrick A. Lewis

Affiliations Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom, School of Pharmacy, University of Reading, Reading, United Kingdom

Thomas Foltynie

Affiliation Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom

George Davey Smith

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

International Parkinson Disease Genomics Consortium

Membership of the International Parkinson Disease Genomics Consortium is provided in the Acknowledgments.

Anette Schrag

Affiliation Department of Clinical Neurosciences, UCL Institute of Neurology, University College London, London, United Kingdom

Andrew J. Lees

Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

John Hardy

Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

Andrew Singleton

Affiliation Laboratory for Neurogenetics, National Institute on Aging National Institutes of Health, Bethesda, Maryland, United States of America

Mike A. Nalls

Affiliations Laboratory for Neurogenetics, National Institute on Aging National Institutes of Health, Bethesda, Maryland, United States of America, Data Tecnica International, Glen Echo, Maryland, United States of America

Neil Pearce

Affiliation Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, United Kingdom

Debbie A. Lawlor

Affiliations MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

Nicholas W. Wood

n.wood@ucl.ac.uk

Affiliation Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom

Competing Interests

AJN reports: grants from Parkinson’s UK, Élan/Prothena Pharmaceuticals, GE Healthcare; shares in LifeLab Ltd; advisory board membership for myHealthPal; honoraria from Office Octopus, Henry Stewart Talks, and Britannia Pharmaceuticals Ltd, all outside of the submitted work. PAL reports grants from MRC, BBSRC, National Institutes of Health, Michael J. Fox Foundation, personal fees from Astex Pharmaceuticals, outside the submitted work. TF reports grants from Michael J Fox Foundation, grants from Brain Research Trust, grants from European Union FP7, grants from John Black Charitable Foundation, personal fees from Medtronic, personal fees from BIAL, personal fees from Profile Pharma, personal fees from Brittania, all outside the submitted work. ASc reports grants from GE Healthcare, outside the submitted work. AJL reports personal fees from Britannia Pharmaceuticals Ltd, BIAL Portela, Profile Pharma Ltd, Teva, Lundbeck, Roche, UCB, NeuroDerm, Nordicinfu Care, Decision Resources, all outside of the submitted work. GDS is a member of the Editorial Board of PLOS Medicine. MAN is a paid consultant/contractor to the NIH. DAL reports grants from UK Medical Research Council, during the conduct of the study; grants from Medical Research council, grants from Wellcome Trust, grants from European Research Council, grants from Roche Diagnostics, grants from Medtronic, grants from Ferring Pharmaceuticals, outside the submitted work. DAK, GH, ASi, AN, EDP-F, JH, NP, TRP, NWW report no relevant disclosures.

Author Contributions

Conceptualization: AJN, DAK, JH, ASc, AJL, ASi, TF, MAN, NP, DAL, NWW. Data curation: AJN, DAK, GH, AN, TRP, EPF, PAL, GDS, DAL, MAN. Formal analysis: AJN, DAK, GH, MAN. Investigation: AJN, DAK, GH, MAN. Methodology: AJN, DAK, GH, PCH, GDS, MAN, DAL, NP, NWW. Software: GH, AN, TRP, MAN. Supervision: DAL, MAN, NWW. Validation: AJN, DAK. Writing – original draft: AJN, DAK, GH, GDS, DAL, NP, MAN, NWW. Writing – review & editing: AN, TRP, PCH, EPF, PAL, TF, ASc, AJL, ASi, PAL.