About the Authors

Banne Nemeth

Affiliations Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, the Netherlands

Raymond A. van Adrichem

Affiliations Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, the Netherlands

Astrid van Hylckama Vlieg

Affiliation Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands

Paolo Bucciarelli

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda–Ospedale Maggiore Policlinico, Milan, Italy

Ida Martinelli

Affiliation Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda–Ospedale Maggiore Policlinico, Milan, Italy

Trevor Baglin

Affiliation Department of Haematology, Addenbrook’s Hospital, Cambridge, United Kingdom

Frits R. Rosendaal

Affiliations Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, the Netherlands

Saskia le Cessie

Affiliations Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands

Suzanne C. Cannegieter

S.C.Cannegieter@lumc.nl

Affiliation Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands

Competing Interests

SCC is a member of the Editorial Board of PLOS Medicine.

Author Contributions

Conceived and designed the experiments: BN RVA SCC FRR. Performed the experiments: BN. Analyzed the data: BN RVA SLC SCC. Contributed reagents/materials/analysis tools: SLC. Wrote the first draft of the manuscript: BN RVA. Contributed to the writing of the manuscript: BN RVA SLC AVHV PB IM TB FRR SCC. Enrolled patients: FRR IM PB TB AVHV. Agree with the manuscript’s results and conclusions: BN RVA SLC AVHV PB IM TB FRR SCC. All authors have read, and confirm that they meet, ICMJE criteria for authorship