About the Authors

Carey E. Gleason

ceg@medicine.wisc.edu

Affiliations School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, United States of America

N. Maritza Dowling

Affiliations School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, United States of America, Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

Whitney Wharton

Affiliations School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, United States of America, Emory Alzheimer’s Disease Research Center, Atlanta, Georgia, United States of America

JoAnn E. Manson

Affiliation Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Virginia M. Miller

Affiliation Departments of Surgery and Physiology & Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America

Craig S. Atwood

Affiliations School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, United States of America

Eliot A. Brinton

Affiliation Utah Foundation for Biomedical Research, Salt Lake City, Utah, United States of America

Marcelle I. Cedars

Affiliation Obstetrics & Gynecology, University of California at San Francisco, San Francisco, California, United States of America

Rogerio A. Lobo

Affiliation Obstetrics & Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

George R. Merriam

† Deceased.

Affiliations VA Puget Sound Health Care System, Tacoma, Washington, United States of America, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Tacoma, Washington, United States of America

Genevieve Neal-Perry

Affiliation Neuroscience and Obstetrics & Gynecology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Nanette F. Santoro

Affiliation Obstetrics & Gynecology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

Hugh S. Taylor

Affiliation Obstetrics & Gynecology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Dennis M. Black

Affiliation Epidemiology & Biostatistics, University of California at San Francisco, San Francisco, California, United States of America

Matthew J. Budoff

Affiliation Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor–UCLA Medical Center, Torrance, California, United States of America

Howard N. Hodis

Affiliation Atherosclerosis Research Unit, University of Southern California, Los Angeles, California, United States of America

Frederick Naftolin

Affiliation Obstetrics & Gynecology, New York University School of Medicine, New York, New York, United States of America

S. Mitchell Harman

Affiliations Kronos Longevity Research Institute, Phoenix, Arizona, United States of America, Division of Endocrinology, Phoenix VA Medical Center, Phoenix, Arizona, United States of America

Sanjay Asthana

Affiliations School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America, Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States of America, Wisconsin Alzheimer’s Disease Research Center, Madison, Wisconsin, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: MIC declared: I have research funding from Nora Therapeutics and Ferring pharmaceuticals. I am a member of ASRM Executive Board. NFS declared: 1. Menogenix: stock options (this is a company that has patented a novel non hormonal treatment for menopausal hot flashes and to date I have not exercised my stock options but would rather report this than give the appearance of not disclosing sufficient information). 2. Bayer, Inc: grant support (this is an investigator initiated grant that is supported by funds given to my institution. I receive no personal funds for this work). SA declared: 1) NIH Grants to support my research—NIA P50 Center Grant to support the Wisconsin Alzheimer's Disease Research Center (ADRC). 2) NIA T32 Training Grant in the Biology of Aging and Age-Related Diseases. 3) NIA RO1 that supported the KEEPS Cognitive and Affective Study. 4) Following Pharma Industry-supported research grants to serve as a site PI to conduct treatment trials in patients with Alzheimer's disease and Mild Cognitive Impairment (MCI): Merck Sharp and Dohme; H. Lundbeck A-S; Toyama Chemical Company. 5) Rockpointe Corporation—I am on the Speaker's Bureau of this science-based education corporation that sponsors CME-accredited education programs. My presentations are on Alzheimer's disease and not related to the focus of the manuscript under review. HST declared: I have served as a consultant to Bayer, Abbvie, Pfizer and Theraputics MD. My University has received grant support toward my work from Pfizer. I have authored papers with employees of Pfizer and Shionogi.

Author Contributions

Conceived and designed the experiments: CEG SA SMH FN. Performed the experiments: EAB MIC RAL JEM GRM VMM GNP NFS HST MJB HNH. Analyzed the data: NMD DMB. Contributed reagents/materials/analysis tools: CSA MJB HNH. Wrote the first draft of the manuscript: CEG. Contributed to the writing of the manuscript: CEG NMD CSA WW SA MH. Enrolled patients: EAB MIC RAL JEM GRM VMM GNP NFS HST SMH. Agree with manuscript results and conclusions: CEG NMD WW CSA EAB MIC RAL JEM GRM VMM GNP NFS HST DMB MJB HNH FN SMH SA. All authors have read, and confirm that they meet, ICMJE requirements for authorship.