Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

Sylvain Rheims; Michel Cucherat; Alexis Arzimanoglou; Philippe Ryvlin

doi:10.1371/journal.pmed.0050166

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Open Access

Peer-reviewed

Research Article

Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

Sylvain Rheims,

Affiliations Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France , CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France
⨯
Michel Cucherat,

Affiliation Department of Clinical Pharmacology, EA 643, Lyon-1 University, Laennec Faculty of Medicine, Lyon, France
⨯
Alexis Arzimanoglou,

Affiliations CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France , Department of Epileptology, Sleep and Pediatric Neurophysiology, Hospices Civils de Lyon, Lyon, France
⨯
Philippe Ryvlin

*To whom correspondence should be addressed. E-mail: ryvlin@cermep.fr

Affiliations Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France , CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France , INSERM U821, Lyon, France
⨯

Greater Response to Placebo in Children Than in Adults: A Systematic Review and Meta-Analysis in Drug-Resistant Partial Epilepsy

Sylvain Rheims,
Michel Cucherat,
Alexis Arzimanoglou,
Philippe Ryvlin

Published: August 12, 2008
https://doi.org/10.1371/journal.pmed.0050166

About the Authors

Sylvain Rheims

Affiliations Department of Functional Neurology and Epileptology, Hospices Civils de Lyon, Lyon, France , CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France

Michel Cucherat

Affiliation Department of Clinical Pharmacology, EA 643, Lyon-1 University, Laennec Faculty of Medicine, Lyon, France

Alexis Arzimanoglou

Affiliations CTRS INSERM-IDEE, Institute for Children and Adolescents with Epilepsy, Hospices Civils de Lyon, Lyon, France , Department of Epileptology, Sleep and Pediatric Neurophysiology, Hospices Civils de Lyon, Lyon, France

Philippe Ryvlin

*To whom correspondence should be addressed. E-mail: ryvlin@cermep.fr

Competing Interests

SR has received speaker fees from Pfizer. MC has no conflict of interest. AA has received speaker or consultant fees from Pfizer, Sanofi-Aventis, GlaxoSmithKline (GSK), Jansen-Cilag, UCB Pharma, EISAI, and Valeant. PR has received speaker fees from Cyberonics, Eisai, GSK, Janssen-Cilag, Novartis, Pfizer, Sanofi-Synthelabo, and UCB; and consultant fees from Cyberonics, GSK, Janssen-Cilag, Novartis, Pfizer, UCB, and Valeant.

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Pediatrics
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Epilepsy
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Randomized controlled trials
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Drug therapy
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