About the Authors

Simon P Mooijaart

To whom correspondence should be addressed. E-mail: s.p.mooijaart@lumc.nl

Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

Jimmy F. P Berbée

Affiliations Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands , Netherlands Organization for Applied Scientific Research—Quality of Life, Gaubius Laboratory, Leiden, Netherlands

Diana van Heemst

Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

Louis M Havekes

Affiliations Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands , Netherlands Organization for Applied Scientific Research—Quality of Life, Gaubius Laboratory, Leiden, Netherlands , Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands

Anton J. M de Craen

Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

P. Eline Slagboom

Affiliation Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands

Patrick C. N Rensen

Affiliations Department of General Internal Medicine, Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands , Netherlands Organization for Applied Scientific Research—Quality of Life, Gaubius Laboratory, Leiden, Netherlands

Rudi G. J Westendorp

Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands

Competing Interests

We declare that all authors on the manuscript are co-inventors on a pending patent application entitled “Apolipoprotein E plasma levels for monitoring and reducing the risk of cardiovascular disease,” of which the contents are based on the results described in the present study.

Author Contributions

SPM, JFPB, DvH, LMH, AJMdC, PES, PCNR, and RGJW were involved in design of the study and interpretation of the results. SPM, JFPB, DvH, PCNR, and RGJW wrote the manuscript. SPM and DvH analyzed the data and RGJW supervised. JFPB determined the apoE levels. AJMdC assisted in statistical analyses. LMH and PES assisted in interpretation of the results. PCNR and RGJW obtained funding. RGJW organized patient data collection.