May 2021

Overview of cell nuclei in a pluripotent zebrafish embryo, illustrating the variety of patterns formed by DNA in different cells. These patterns were mapped to multiplicative cascades, capturing DNA distribution across length scales. This mapping also relates the DNA distribution in these cells to a wider class of multi-fractal systems, including, for example, clouds in the sky or cracks in the soil. The image shows an optical section through a sphere stage embryo acquired by STimulated Emission Depletion (STED) microscopy, field of view 155-by-155 micrometers.

Image Credit: Amra Noa Lennart Hilbert, Karlsruhe Institute of Technology, Institute of Biological and Chemical System; image acquired at Karlsruhe Center for Optics and Photonics; 2021

Editorials

Ten simple rules to cultivate transdisciplinary collaboration in data science

Faryad Sahneh, Meghan A. Balk, Marina Kisley, Chi-kwan Chan, Mercury Fox, Brian Nord, Eric Lyons, Tyson Swetnam, Daniela Huppenkothen, Will Sutherland, Ramona L. Walls, Daven P. Quinn, Tonantzin Tarin, David LeBauer, David Ribes, Dunbar P. Birnie III, Carol Lushbough, Eric Carr, Grey Nearing, Jeremy Fischer, Kevin Tyle, Luis Carrasco, Meagan Lang, Peter W. Rose, Richard R. Rushforth, Samapriya Roy, Thomas Matheson, Tina Lee, C. Titus Brown, Tracy K. Teal, Monica Papeș, Stephen Kobourov, Nirav Merchant

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008879

Ten simple rules to make your publication look better

Friederike Ehrhart, Chris T. Evelo

PLOS Computational Biology: published May 20, 2021 | https://doi.org/10.1371/journal.pcbi.1008938

Ten simple rules for productive lab meetings

Nigel Golden, Kadambari Devarajan, Cathleen Balantic, Joseph Drake, Michael T. Hallworth, Toni Lyn Morelli

PLOS Computational Biology: published May 27, 2021 | https://doi.org/10.1371/journal.pcbi.1008953

Education Articles

Ten steps to investigate a cellular system with mathematical modeling

Jasia King, Kerbaï Saïd Eroumé, Roman Truckenmüller, Stefan Giselbrecht, Ann E. Cowan, Leslie Loew, Aurélie Carlier

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008921

A constructivist-based proposal for bioinformatics teaching practices during lockdown

Cristóbal Gallardo-Alba, Björn Grüning, Beatriz Serrano-Solano

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008922

Fostering accessible online education using Galaxy as an e-learning platform

Beatriz Serrano-Solano, Melanie C. Föll, Cristóbal Gallardo-Alba, Anika Erxleben, Helena Rasche, Saskia Hiltemann, Matthias Fahrner, Mark J. Dunning, Marcel H. Schulz, Beáta Scholtz, Dave Clements, Anton Nekrutenko, Bérénice Batut, Björn A. Grüning

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008923

What do Eulerian and Hamiltonian cycles have to do with genome assembly?

Paul Medvedev, Mihai Pop

PLOS Computational Biology: published May 20, 2021 | https://doi.org/10.1371/journal.pcbi.1008928

Research Articles

Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10

Leonard Campanello, Maria K. Traver, Hari Shroff, Brian C. Schaefer, Wolfgang Losert

PLOS Computational Biology: published May 20, 2021 | https://doi.org/10.1371/journal.pcbi.1007986

Pseudocell Tracer—A method for inferring dynamic trajectories using scRNAseq and its application to B cells undergoing immunoglobulin class switch recombination

Derek Reiman, Godhev Kumar Manakkat Vijay, Heping Xu, Andrew Sonin, Dianyu Chen, Nathan Salomonis, Harinder Singh, Aly A. Khan

PLOS Computational Biology: published May 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008094

A first-takes-all model of centriole copy number control based on cartwheel elongation

Marco António Dias Louro, Mónica Bettencourt-Dias, Jorge Carneiro

PLOS Computational Biology: published May 10, 2021 | https://doi.org/10.1371/journal.pcbi.1008359

Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type

Susana Andrea Contreras, Jan-Hendrik Schleimer, Allan T. Gulledge, Susanne Schreiber

PLOS Computational Biology: published May 27, 2021 | https://doi.org/10.1371/journal.pcbi.1008510

Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition

Christian Schulz, Tjasa Kumelj, Emil Karlsen, Eivind Almaas

PLOS Computational Biology: published May 24, 2021 | https://doi.org/10.1371/journal.pcbi.1008528

Calculation of the force field required for nucleus deformation during cell migration through constrictions

Ian D. Estabrook, Hawa Racine Thiam, Matthieu Piel, Rhoda J. Hawkins

PLOS Computational Biology: published May 24, 2021 | https://doi.org/10.1371/journal.pcbi.1008592

Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1

Shalmali Kharche, Manali Joshi, Amitabha Chattopadhyay, Durba Sengupta

PLOS Computational Biology: published May 20, 2021 | https://doi.org/10.1371/journal.pcbi.1008593

Sensory modulation of gait characteristics in human locomotion: A neuromusculoskeletal modeling study

Andrea Di Russo, Dimitar Stanev, Stéphane Armand, Auke Ijspeert

PLOS Computational Biology: published May 19, 2021 | https://doi.org/10.1371/journal.pcbi.1008594

What we can and what we cannot see with extracellular multielectrodes

Chaitanya Chintaluri, Marta Bejtka, Władysław Średniawa, Michał Czerwiński, Jakub M. Dzik, Joanna Jędrzejewska-Szmek, Kacper Kondrakiewicz, Ewa Kublik, Daniel K. Wójcik

PLOS Computational Biology: published May 14, 2021 | https://doi.org/10.1371/journal.pcbi.1008615

Patterns of selection against centrosome amplification in human cell lines

Marco António Dias Louro, Mónica Bettencourt-Dias, Claudia Bank

PLOS Computational Biology: published May 12, 2021 | https://doi.org/10.1371/journal.pcbi.1008765

Numerical analysis of the impact of cytoskeletal actin filament density alterations onto the diffusive vesicle-mediated cell transport

Daniel Ch. Haspinger, Sandra Klinge, Gerhard A. Holzapfel

PLOS Computational Biology: published May 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008784

Extracting representations of cognition across neuroimaging studies improves brain decoding

Arthur Mensch, Julien Mairal, Bertrand Thirion, Gaël Varoquaux

PLOS Computational Biology: published May 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008795

Modelling optimal vaccination strategy for SARS-CoV-2 in the UK

Sam Moore, Edward M. Hill, Louise Dyson, Michael J. Tildesley, Matt J. Keeling

PLOS Computational Biology: published May 6, 2021 | https://doi.org/10.1371/journal.pcbi.1008849

Hierarchical semantic composition of biosimulation models using bond graphs

Niloofar Shahidi, Michael Pan, Soroush Safaei, Kenneth Tran, Edmund J. Crampin, David P. Nickerson

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008859

Hypoxic pulmonary vasoconstriction as a regulator of alveolar-capillary oxygen flux: A computational model of ventilation-perfusion matching

Andrew D. Marquis, Filip Jezek, David J. Pinsky, Daniel A. Beard

PLOS Computational Biology: published May 6, 2021 | https://doi.org/10.1371/journal.pcbi.1008861

CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation

Christopher J. Arthurs, Rostislav Khlebnikov, Alex Melville, Marija Marčan, Alberto Gomez, Desmond Dillon-Murphy, Federica Cuomo, Miguel Silva Vieira, Jonas Schollenberger, Sabrina R. Lynch, Christopher Tossas-Betancourt, Kritika Iyer, Sara Hopper, Elizabeth Livingston, Pouya Youssefi, Alia Noorani, Sabrina Ben Ahmed, Foeke J. H. Nauta, Theodorus M. J. van Bakel, Yunus Ahmed, Petrus A. J. van Bakel, Jonathan Mynard, Paolo Di Achille, Hamid Gharahi, Kevin D. Lau, Vasilina Filonova, Miquel Aguirre, Nitesh Nama, Nan Xiao, Seungik Baek, Krishna Garikipati, Onkar Sahni, David Nordsletten, C. Alberto Figueroa

PLOS Computational Biology: published May 10, 2021 | https://doi.org/10.1371/journal.pcbi.1008881

Leveraging eQTLs to identify individual-level tissue of interest for a complex trait

Arunabha Majumdar, Claudia Giambartolomei, Na Cai, Tanushree Haldar, Tommer Schwarz, Michael Gandal, Jonathan Flint, Bogdan Pasaniuc

PLOS Computational Biology: published May 21, 2021 | https://doi.org/10.1371/journal.pcbi.1008915

Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions

Grímur Hjörleifsson Eldjárn, Andrew Ramsay, Justin J. J. van der Hooft, Katherine R. Duncan, Sylvia Soldatou, Juho Rousu, Rónán Daly, Joe Wandy, Simon Rogers

PLOS Computational Biology: published May 4, 2021 | https://doi.org/10.1371/journal.pcbi.1008920

Incorporating the speciation process into species delimitation

Jeet Sukumaran, Mark T. Holder, L. Lacey Knowles

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008924

Global importance analysis: An interpretability method to quantify importance of genomic features in deep neural networks

Peter K. Koo, Antonio Majdandzic, Matthew Ploenzke, Praveen Anand, Steffan B. Paul

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008925

Red blood cell phenotyping from 3D confocal images using artificial neural networks

Greta Simionato, Konrad Hinkelmann, Revaz Chachanidze, Paola Bianchi, Elisa Fermo, Richard van Wijk, Marc Leonetti, Christian Wagner, Lars Kaestner, Stephan Quint

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008934

Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?

Jon Kapla, Ismael Rodríguez-Espigares, Flavio Ballante, Jana Selent, Jens Carlsson

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1008936

Agent-based model provides insight into the mechanisms behind failed regeneration following volumetric muscle loss injury

Amanda M. Westman, Shayn M. Peirce, George J. Christ, Silvia S. Blemker

PLOS Computational Biology: published May 10, 2021 | https://doi.org/10.1371/journal.pcbi.1008937

How multisite phosphorylation impacts the conformations of intrinsically disordered proteins

Fan Jin, Frauke Gräter

PLOS Computational Biology: published May 4, 2021 | https://doi.org/10.1371/journal.pcbi.1008939

Effects of incomplete inter-hospital network data on the assessment of transmission dynamics of hospital-acquired infections

Hanjue Xia, Johannes Horn, Monika J. Piotrowska, Konrad Sakowski, André Karch, Hannan Tahir, Mirjam Kretzschmar, Rafael Mikolajczyk

PLOS Computational Biology: published May 6, 2021 | https://doi.org/10.1371/journal.pcbi.1008941

Small subpopulations of β-cells do not drive islet oscillatory [Ca²⁺] dynamics via gap junction communication

JaeAnn M. Dwulet, Jennifer K. Briggs, Richard K. P. Benninger

PLOS Computational Biology: published May 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008948

Deep template-based protein structure prediction

Fandi Wu, Jinbo Xu

PLOS Computational Biology: published May 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008954

Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder

Mads L. Pedersen, Maria Ironside, Ken-ichi Amemori, Callie L. McGrath, Min S. Kang, Ann M. Graybiel, Diego A. Pizzagalli, Michael J. Frank

PLOS Computational Biology: published May 10, 2021 | https://doi.org/10.1371/journal.pcbi.1008955

A model of dopamine and serotonin-kynurenine metabolism in cortisolemia: Implications for depression

Felipe Dalvi-Garcia, Luis L. Fonseca, Ana Tereza R. Vasconcelos, Cecilia Hedin-Pereira, Eberhard O. Voit

PLOS Computational Biology: published May 10, 2021 | https://doi.org/10.1371/journal.pcbi.1008956

On the effect of phylogenetic correlations in coevolution-based contact prediction in proteins

Edwin Rodriguez Horta, Martin Weigt

PLOS Computational Biology: published May 24, 2021 | https://doi.org/10.1371/journal.pcbi.1008957

Balanced networks under spike-time dependent plasticity

Alan Eric Akil, Robert Rosenbaum, Krešimir Josić

PLOS Computational Biology: published May 12, 2021 | https://doi.org/10.1371/journal.pcbi.1008958

Estimating direct and spill-over impacts of political elections on COVID-19 transmission using synthetic control methods

Jue Tao Lim, Kenwin Maung, Sok Teng Tan, Suan Ee Ong, Jane Mingjie Lim, Joel Ruihan Koo, Haoyang Sun, Minah Park, Ken Wei Tan, Joanne Yoong, Alex R. Cook, Borame Sue Lee Dickens

PLOS Computational Biology: published May 27, 2021 | https://doi.org/10.1371/journal.pcbi.1008959

Model guided trait-specific co-expression network estimation as a new perspective for identifying molecular interactions and pathways

Juho A. J. Kontio, Tanja Pyhäjärvi, Mikko J. Sillanpää

PLOS Computational Biology: published May 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008960

Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma

Georg E. Luebeck, Thomas L. Vaughan, Kit Curtius, William D. Hazelton

PLOS Computational Biology: published May 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008961

Performance assessment of sample-specific network control methods for bulk and single-cell biological data analysis

Wei-Feng Guo, Xiangtian Yu, Qian-Qian Shi, Jing Liang, Shao-Wu Zhang, Tao Zeng

PLOS Computational Biology: published May 6, 2021 | https://doi.org/10.1371/journal.pcbi.1008962

Cortical propagation tracks functional recovery after stroke

Gloria Cecchini, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Curzio Checcucci, Emilia Conti, Ihusan Adam, Duccio Fanelli, Roberto Livi, Francesco Saverio Pavone, Thomas Kreuz

PLOS Computational Biology: published May 17, 2021 | https://doi.org/10.1371/journal.pcbi.1008963

Maximally efficient prediction in the early fly visual system may support evasive flight maneuvers

Siwei Wang, Idan Segev, Alexander Borst, Stephanie Palmer

PLOS Computational Biology: published May 20, 2021 | https://doi.org/10.1371/journal.pcbi.1008965

Antibody Watch: Text mining antibody specificity from the literature

Chun-Nan Hsu, Chia-Hui Chang, Thamolwan Poopradubsil, Amanda Lo, Karen A. William, Ko-Wei Lin, Anita Bandrowski, Ibrahim Burak Ozyurt, Jeffrey S. Grethe, Maryann E. Martone

PLOS Computational Biology: published May 27, 2021 | https://doi.org/10.1371/journal.pcbi.1008967

Sequence learning recodes cortical representations instead of strengthening initial ones

Kristjan Kalm, Dennis Norris

PLOS Computational Biology: published May 24, 2021 | https://doi.org/10.1371/journal.pcbi.1008969

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure

Saskia Haupt, Alexander Zeilmann, Aysel Ahadova, Hendrik Bläker, Magnus von Knebel Doeberitz, Matthias Kloor, Vincent Heuveline

PLOS Computational Biology: published May 18, 2021 | https://doi.org/10.1371/journal.pcbi.1008970

A method for achieving complete microbial genomes and improving bins from metagenomics data

Lauren M. Lui, Torben N. Nielsen, Adam P. Arkin

PLOS Computational Biology: published May 7, 2021 | https://doi.org/10.1371/journal.pcbi.1008972

Active head rolls enhance sonar-based auditory localization performance

Lakshitha P. Wijesinghe, Melville J. Wohlgemuth, Richard H. Y. So, Jochen Triesch, Cynthia F. Moss, Bertram E. Shi

PLOS Computational Biology: published May 10, 2021 | https://doi.org/10.1371/journal.pcbi.1008973

The hierarchical packing of euchromatin domains can be described as multiplicative cascades

Amra Noa, Hui-Shun Kuan, Vera Aschmann, Vasily Zaburdaev, Lennart Hilbert

PLOS Computational Biology: published May 5, 2021 | https://doi.org/10.1371/journal.pcbi.1008974

Modelling 3D saccade generation by feedforward optimal control

Akhil John, Carlos Aleluia, A. John Van Opstal, Alexandre Bernardino

PLOS Computational Biology: published May 24, 2021 | https://doi.org/10.1371/journal.pcbi.1008975

MetaGSCA: A tool for meta-analysis of gene set differential coexpression

Yan Guo, Hui Yu, Haocan Song, Jiapeng He, Olufunmilola Oyebamiji, Huining Kang, Jie Ping, Scott Ness, Yu Shyr, Fei Ye

PLOS Computational Biology: published May 4, 2021 | https://doi.org/10.1371/journal.pcbi.1008976

Swarm: A federated cloud framework for large-scale variant analysis

Amir Bahmani, Kyle Ferriter, Vandhana Krishnan, Arash Alavi, Amir Alavi, Philip S. Tsao, Michael P. Snyder, Cuiping Pan

PLOS Computational Biology: published May 12, 2021 | https://doi.org/10.1371/journal.pcbi.1008977

scHiCTools: A computational toolbox for analyzing single-cell Hi-C data

Xinjun Li, Fan Feng, Hongxi Pu, Wai Yan Leung, Jie Liu

PLOS Computational Biology: published May 18, 2021 | https://doi.org/10.1371/journal.pcbi.1008978

VCF2CAPS–A high-throughput CAPS marker design from VCF files and its test-use on a genotyping-by-sequencing (GBS) dataset

Wojciech Wesołowski, Beata Domnicz, Joanna Augustynowicz, Marek Szklarczyk

PLOS Computational Biology: published May 20, 2021 | https://doi.org/10.1371/journal.pcbi.1008980

Predicting mean ribosome load for 5’UTR of any length using deep learning

Alexander Karollus, Žiga Avsec, Julien Gagneur

PLOS Computational Biology: published May 10, 2021 | https://doi.org/10.1371/journal.pcbi.1008982

Elucidation of trophic interactions in an unusual single-cell nitrogen-fixing symbiosis using metabolic modeling

Debolina Sarkar, Marine Landa, Anindita Bandyopadhyay, Himadri B. Pakrasi, Jonathan P. Zehr, Costas D. Maranas

PLOS Computational Biology: published May 7, 2021 | https://doi.org/10.1371/journal.pcbi.1008983

Global disruption in excitation-inhibition balance can cause localized network dysfunction and Schizophrenia-like context-integration deficits

Olivia L. Calvin, A. David Redish

PLOS Computational Biology: published May 25, 2021 | https://doi.org/10.1371/journal.pcbi.1008985

Targeted modification of the Per2 clock gene alters circadian function in mPer2^luciferase (mPer2^Luc) mice

Martin R. Ralph, Shu-qun Shi, Carl H. Johnson, Pavel Houdek, Tenjin C. Shrestha, Priya Crosby, John S. O’Neill, Martin Sládek, Adam R. Stinchcombe, Alena Sumová

PLOS Computational Biology: published May 28, 2021 | https://doi.org/10.1371/journal.pcbi.1008987

Molecular dynamics shows complex interplay and long-range effects of post-translational modifications in yeast protein interactions

Nikolina Šoštarić, Vera van Noort

PLOS Computational Biology: published May 12, 2021 | https://doi.org/10.1371/journal.pcbi.1008988

Finding recurrent RNA structural networks with fast maximal common subgraphs of edge-colored graphs

Antoine Soulé, Vladimir Reinharz, Roman Sarrazin-Gendron, Alain Denise, Jérôme Waldispühl

PLOS Computational Biology: published May 28, 2021 | https://doi.org/10.1371/journal.pcbi.1008990

Robust switches in thalamic network activity require a timescale separation between sodium and T-type calcium channel activations

Kathleen Jacquerie, Guillaume Drion

PLOS Computational Biology: published May 18, 2021 | https://doi.org/10.1371/journal.pcbi.1008997

PRER: A patient representation with pairwise relative expression of proteins on biological networks

Halil İbrahim Kuru, Mustafa Buyukozkan, Oznur Tastan

PLOS Computational Biology: published May 26, 2021 | https://doi.org/10.1371/journal.pcbi.1008998

Real-time single-cell characterization of the eukaryotic transcription cycle reveals correlations between RNA initiation, elongation, and cleavage

Jonathan Liu, Donald Hansen, Elizabeth Eck, Yang Joon Kim, Meghan Turner, Simon Alamos, Hernan G. Garcia

PLOS Computational Biology: published May 18, 2021 | https://doi.org/10.1371/journal.pcbi.1008999

NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis

Marko Šterk, Lidija Križančić Bombek, Maša Skelin Klemen, Marjan Slak Rupnik, Marko Marhl, Andraž Stožer, Marko Gosak

PLOS Computational Biology: published May 11, 2021 | https://doi.org/10.1371/journal.pcbi.1009002

Effects of subclinical depression on prefrontal–striatal model-based and model-free learning

Suyeon Heo, Yoondo Sung, Sang Wan Lee

PLOS Computational Biology: published May 14, 2021 | https://doi.org/10.1371/journal.pcbi.1009003

Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device–demonstrative in silico study

Kazuki Kuga, Kazuhide Ito, Wenhao Chen, Ping Wang, Jeff Fowles, Kazukiyo Kumagai

PLOS Computational Biology: published May 13, 2021 | https://doi.org/10.1371/journal.pcbi.1009004

The gradient clusteron: A model neuron that learns to solve classification tasks via dendritic nonlinearities, structural plasticity, and gradient descent

Toviah Moldwin, Menachem Kalmenson, Idan Segev

PLOS Computational Biology: published May 24, 2021 | https://doi.org/10.1371/journal.pcbi.1009015

A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila

Claudio D. T. Barros, Maira A. Cardoso, Paulo M. Bisch, Helena M. Araujo, Francisco J. P. Lopes

PLOS Computational Biology: published May 27, 2021 | https://doi.org/10.1371/journal.pcbi.1009040

A deep learning algorithm for 3D cell detection in whole mouse brain image datasets

Adam L. Tyson, Charly V. Rousseau, Christian J. Niedworok, Sepiedeh Keshavarzi, Chryssanthi Tsitoura, Lee Cossell, Molly Strom, Troy W. Margrie

PLOS Computational Biology: published May 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009074

Corrections

Correction: PPM-Decay: A computational model of auditory prediction with memory decay

Peter M. C. Harrison, Roberta Bianco, Maria Chait, Marcus T. Pearce

PLOS Computational Biology: published May 26, 2021 | https://doi.org/10.1371/journal.pcbi.1008995

Correction: Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression

Xiangyu Yao, Shihoko Kojima, Jing Chen

PLOS Computational Biology: published May 26, 2021 | https://doi.org/10.1371/journal.pcbi.1009065

Cover

DNA distribution in nuclei of a pluripotent zebrafish embryo

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