This three-dimensional rendering illustrates light hitting a neuron bearing light-sensitive channels. When light impinges upon the neuron, the channels open, electrically exciting the neuron (depicted as white highlights). (See Börgers et al., doi:10.1371/journal.pcbi.1002362)
Image Credit: Courtesy of Ed Boyden, McGovern Institute for Brain Research at MIT, and Sputnik Animation.
Reviews
Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges
PLOS Computational Biology: published February 23, 2012 | https://doi.org/10.1371/journal.pcbi.1002375
The Efficiency of the Human CD8+ T Cell Response: How Should We Quantify It, What Determines It, and Does It Matter?
PLOS Computational Biology: published February 23, 2012 | https://doi.org/10.1371/journal.pcbi.1002381
Research Articles
A Cell-based Computational Modeling Approach for Developing Site-Directed Molecular Probes
PLOS Computational Biology: published February 23, 2012 | https://doi.org/10.1371/journal.pcbi.1002378
Structural Consensus among Antibodies Defines the Antigen Binding Site
PLOS Computational Biology: published February 23, 2012 | https://doi.org/10.1371/journal.pcbi.1002388
Effects of Electrical and Structural Remodeling on Atrial Fibrillation Maintenance: A Simulation Study
PLOS Computational Biology: published February 23, 2012 | https://doi.org/10.1371/journal.pcbi.1002390
Robust Detection of Hierarchical Communities from Escherichia coli Gene Expression Data
PLOS Computational Biology: published February 23, 2012 | https://doi.org/10.1371/journal.pcbi.1002391
Comparison of Insertional RNA Editing in Myxomycetes
PLOS Computational Biology: published February 23, 2012 | https://doi.org/10.1371/journal.pcbi.1002400
Use It and Improve It or Lose It: Interactions between Arm Function and Use in Humans Post-stroke
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002343
On the Effect of Thermodynamic Equilibrium on the Assembly Efficiency of Complex Multi-Layered Virus-Like Particles (VLP): the Case of Rotavirus VLP
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002367
Dynamic Energy Landscapes of Riboswitches Help Interpret Conformational Rearrangements and Function
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002368
A Race between Tumor Immunoescape and Genome Maintenance Selects for Optimum Levels of (epi)genetic Instability
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002370
Joint Analysis of Multiple Metagenomic Samples
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002373
Branch Mode Selection during Early Lung Development
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002377
Modeling Cortisol Dynamics in the Neuro-endocrine Axis Distinguishes Normal, Depression, and Post-traumatic Stress Disorder (PTSD) in Humans
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002379
DOGS: Reaction-Driven de novo Design of Bioactive Compounds
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002380
Paradoxical Evidence Integration in Rapid Decision Processes
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002382
On the Use of Gene Ontology Annotations to Assess Functional Similarity among Orthologs and Paralogs: A Short Report
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002386
Noise and Robustness in Phyllotaxis
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002389
The Role of Conserved Waters in Conformational Transitions of Q61H K-ras
PLOS Computational Biology: published February 16, 2012 | https://doi.org/10.1371/journal.pcbi.1002394
Using Functional Signatures to Identify Repositioned Drugs for Breast, Myelogenous Leukemia and Prostate Cancer
PLOS Computational Biology: published February 9, 2012 | https://doi.org/10.1371/journal.pcbi.1002347
Minimal Size of Cell Assemblies Coordinated by Gamma Oscillations
PLOS Computational Biology: published February 9, 2012 | https://doi.org/10.1371/journal.pcbi.1002362
Control of Whole Heart Geometry by Intramyocardial Mechano-Feedback: A Model Study
PLOS Computational Biology: published February 9, 2012 | https://doi.org/10.1371/journal.pcbi.1002369
Multi-Scale Modeling of HIV Infection in vitro and APOBEC3G-Based Anti-Retroviral Therapy
PLOS Computational Biology: published February 9, 2012 | https://doi.org/10.1371/journal.pcbi.1002371
Subcellular Location of PKA Controls Striatal Plasticity: Stochastic Simulations in Spiny Dendrites
PLOS Computational Biology: published February 9, 2012 | https://doi.org/10.1371/journal.pcbi.1002383
Human Visual Search Does Not Maximize the Post-Saccadic Probability of Identifying Targets
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002342
In silico Experimentation of Glioma Microenvironment Development and Anti-tumor Therapy
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002355
Positive Evolutionary Selection of an HD Motif on Alzheimer Precursor Protein Orthologues Suggests a Functional Role
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002356
Stochastic De-repression of Rhodopsins in Single Photoreceptors of the Fly Retina
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002357
Early Warning Signals for Critical Transitions: A Generalized Modeling Approach
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002360
OptCom: A Multi-Level Optimization Framework for the Metabolic Modeling and Analysis of Microbial Communities
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002363
Viral Proteins Acquired from a Host Converge to Simplified Domain Architectures
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002364
Novel Approach to Meta-Analysis of Microarray Datasets Reveals Muscle Remodeling-related Drug Targets and Biomarkers in Duchenne Muscular Dystrophy
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002365
Developmental Maturation of Dynamic Causal Control Signals in Higher-Order Cognition: A Neurocognitive Network Model
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002374
Integrating Flux Balance Analysis into Kinetic Models to Decipher the Dynamic Metabolism of Shewanella oneidensis MR-1
PLOS Computational Biology: published February 2, 2012 | https://doi.org/10.1371/journal.pcbi.1002376