September 2009

This figure illustrates two contrasted epochs of sub-threshold (and sometimes spiking) responses that can be measured intracellularly in the primary visual cortex of a cat during presentation of a drifting grating (left, red trace) followed by the visuo-oculomotor exploration of a natural scene (right, blue trace). The corresponding dynamics of the membrane potential fluctuations exhibit long-range correlations for the low dimension periodic stimulus (the curtain). These correlations are strongly reduced when the visual system is driven by a natural scene (see El Boustani et al., doi:10.1371/journal.pcbi.1000519).

Image Credit: UNIC-CNRS

Editorial

Ten Simple Rules for Chairing a Scientific Session

Alex Bateman, Philip E. Bourne

PLOS Computational Biology: published September 25, 2009 | https://doi.org/10.1371/journal.pcbi.1000517

Perspective

Brief Overview of Bioinformatics Activities in Singapore

Frank Eisenhaber, Chee-Keong Kwoh, See-Kiong Ng, Wing-King Sung, Limsoon Wong

PLOS Computational Biology: published September 25, 2009 | https://doi.org/10.1371/journal.pcbi.1000508

Eradication of Chronic Myeloid Leukemia Stem Cells: A Novel Mathematical Model Predicts No Therapeutic Benefit of Adding G-CSF to Imatinib

Jasmine Foo, Mark W. Drummond, Bayard Clarkson, Tessa Holyoake, Franziska Michor

PLOS Computational Biology: published September 11, 2009 | https://doi.org/10.1371/journal.pcbi.1000503

Interrogating and Predicting Tolerated Sequence Diversity in Protein Folds: Application to E. elaterium Trypsin Inhibitor-II Cystine-Knot Miniprotein

Jennifer L. Lahti, Adam P. Silverman, Jennifer R. Cochran

PLOS Computational Biology: published September 4, 2009 | https://doi.org/10.1371/journal.pcbi.1000499

Cover

The signature of stimulus-driven correlations in visual cortical synaptic activity.

Editorial

Ten Simple Rules for Chairing a Scientific Session

Perspective

Brief Overview of Bioinformatics Activities in Singapore

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