Figures
Centripetal growth in the basal and the second layers in the corneal epithelium
A Voronoi cell-based simulation is employed to model cell movement, proliferation, and delamination, incorporating biophysical forces acting both within and between cells and across epithelial layers. The simulation demonstrates centripetal growth in the basal (left panel) and second (right panel) layers of the corneal epithelium. Limbal epithelial stem cells (LESCs) are represented by coloured points located at the periphery of the basal layer, while the colors of cells within the domain indicate distinct LESC lineages. Joniani et al. 2026
Image Credit: Neda Khodabakhsh Joniani
Citation: (2026) PLoS Computational Biology Issue Image | Vol. 22(2) March 2026. PLoS Comput Biol 22(2): ev22.i02. https://doi.org/10.1371/image.pcbi.v22.i02
Published: March 20, 2026
Copyright: © 2026 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A Voronoi cell-based simulation is employed to model cell movement, proliferation, and delamination, incorporating biophysical forces acting both within and between cells and across epithelial layers. The simulation demonstrates centripetal growth in the basal (left panel) and second (right panel) layers of the corneal epithelium. Limbal epithelial stem cells (LESCs) are represented by coloured points located at the periphery of the basal layer, while the colors of cells within the domain indicate distinct LESC lineages. Joniani et al. 2026
Image Credit: Neda Khodabakhsh Joniani