Figures
Stimulation-induced electric field modeling in the mouse brain using EFMouse
We introduce EFMouse, an open-source toolbox to model the intracranial electric fields produced by current stimulation and generate predictions that can be tested with mice in-vivo recordings. The image shows the electric field generated by a transcranial direct current stimulation (tDCS) montage targeting the left visual cortex, with four skin anodes surrounding a craniotomy, and one cathode in the back. EFMouse can model cranial recording windows, placement of stimulation electrodes anywhere in or on the animal body, and introduces novel ways to report field predictions, including measures of focality, direction homogeneity and quantification based on Allen Mouse Brain Atlas regions. Sanchez-Romero et al. 2025
Image Credit: Ruben Sanchez-Romero and Bart Krekelberg
Citation: (2025) PLoS Computational Biology Issue Image | Vol. 21(9) October 2025. PLoS Comput Biol 21(9): ev21.i09. https://doi.org/10.1371/image.pcbi.v21.i09
Published: October 8, 2025
Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We introduce EFMouse, an open-source toolbox to model the intracranial electric fields produced by current stimulation and generate predictions that can be tested with mice in-vivo recordings. The image shows the electric field generated by a transcranial direct current stimulation (tDCS) montage targeting the left visual cortex, with four skin anodes surrounding a craniotomy, and one cathode in the back. EFMouse can model cranial recording windows, placement of stimulation electrodes anywhere in or on the animal body, and introduces novel ways to report field predictions, including measures of focality, direction homogeneity and quantification based on Allen Mouse Brain Atlas regions. Sanchez-Romero et al. 2025
Image Credit: Ruben Sanchez-Romero and Bart Krekelberg