Figures
Calorphor
The mechanism by which thermosensitive ion channels translate temperature increase to gate activation is hidden within a network of temperature-sensitive residue interactions. The different temperature-dependent interaction modes which promote activation dynamics are revealed with replica exchange molecular dynamics and machine learning. Regions of the structure characterized by specific modes are depicted here in various colors. Burns et al 2023
Image Credit: Dan Burns
Citation: (2023) PLoS Computational Biology Issue Image | Vol. 19(10) November 2023. PLoS Comput Biol 19(10): ev19.i10. https://doi.org/10.1371/image.pcbi.v19.i10
Published: November 1, 2023
Copyright: © 2023 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The mechanism by which thermosensitive ion channels translate temperature increase to gate activation is hidden within a network of temperature-sensitive residue interactions. The different temperature-dependent interaction modes which promote activation dynamics are revealed with replica exchange molecular dynamics and machine learning. Regions of the structure characterized by specific modes are depicted here in various colors. Burns et al 2023
Image Credit: Dan Burns