Figures
Cross-Scale Relationships in 3D Chromosomal Organization
This figure presents a complex map of human chromosome 10, showing DNA interactions in three dimensions and cross-scale folding relationships. Each filled circle represents a specific chromosome region whose radius corresponds to the region’s length. The image center depicts the entire chromosome as one giant 3D community that splits when moving toward the outer rim along the lines indicating the folding pathways. Some regions neatly nest within larger ones, while others obey different patterns. This variation is critical for understanding how our chromosomes fold and function. For example, neatly nested regions often associate with transcriptionally active chromatin. Bernenko et al 2023
Image Credit: Dolores Bernenko, dolores.bernenko@umu.se
Citation: (2023) PLoS Computational Biology Issue Image | Vol. 19(7) August 2023. PLoS Comput Biol 19(7): ev19.i07. https://doi.org/10.1371/image.pcbi.v19.i07
Published: August 1, 2023
Copyright: © 2023 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This figure presents a complex map of human chromosome 10, showing DNA interactions in three dimensions and cross-scale folding relationships. Each filled circle represents a specific chromosome region whose radius corresponds to the region’s length. The image center depicts the entire chromosome as one giant 3D community that splits when moving toward the outer rim along the lines indicating the folding pathways. Some regions neatly nest within larger ones, while others obey different patterns. This variation is critical for understanding how our chromosomes fold and function. For example, neatly nested regions often associate with transcriptionally active chromatin. Bernenko et al 2023
Image Credit: Dolores Bernenko, dolores.bernenko@umu.se