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HaploCart: Human mtDNA HaploGroup Classification using a Pangenomic Reference Graph
With Bayesian inference and a pangenomic reference graph framework, HaploCart overcomes reference bias in mitochondrial haplogroup assignments, outperforming current tools. Robust to lower coverage sequences, it delivers phylogenetically-aware confidence scores, unbiased towards any haplogroup. A user-friendly tool accepting consensus FASTA, FASTQ, or GAM files. Ruben et al 2023
Image Credit: Gabriel Renaud, Midjourney
Citation: (2023) PLoS Computational Biology Issue Image | Vol. 19(6) July 2023. PLoS Comput Biol 19(6): ev19.i06. https://doi.org/10.1371/image.pcbi.v19.i06
Published: July 6, 2023
Copyright: © 2023 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
With Bayesian inference and a pangenomic reference graph framework, HaploCart overcomes reference bias in mitochondrial haplogroup assignments, outperforming current tools. Robust to lower coverage sequences, it delivers phylogenetically-aware confidence scores, unbiased towards any haplogroup. A user-friendly tool accepting consensus FASTA, FASTQ, or GAM files. Ruben et al 2023
Image Credit: Gabriel Renaud, Midjourney