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Digital twin predicting diet response before and after long-term fasting
Today, there is great interest in diets proposing new macronutrient compositions and fasting schedules. Unfortunately, there is little consensus regarding the impact these new diets have on our metabolism. We lack an approach for integrating partial insights derived from different clinical studies with different measured variables - in different situations and on different populations – into a useful and interconnected big picture. Herein, we present such an integrating tool: a multi-organ and multi-timescale ODE model of human metabolism. This tool predicts both mean human metabolism responses to meals and fasting schedules, and is capable of making person-specific predictions. Silfvergren et al
Image Credit: Christian Simonsson, Linköping University, Sweden.
Citation: (2022) PLoS Computational Biology Issue Image | Vol. 18(9) September 2022. PLoS Comput Biol 18(9): ev18.i09. https://doi.org/10.1371/image.pcbi.v18.i09
Published: September 30, 2022
Copyright: © 2022 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Today, there is great interest in diets proposing new macronutrient compositions and fasting schedules. Unfortunately, there is little consensus regarding the impact these new diets have on our metabolism. We lack an approach for integrating partial insights derived from different clinical studies with different measured variables - in different situations and on different populations – into a useful and interconnected big picture. Herein, we present such an integrating tool: a multi-organ and multi-timescale ODE model of human metabolism. This tool predicts both mean human metabolism responses to meals and fasting schedules, and is capable of making person-specific predictions. Silfvergren et al
Image Credit: Christian Simonsson, Linköping University, Sweden.