Figures
High resolution structure of Staphyloccus aureus dihydrofolate reductase (DHFR) with inhibitor R-27 (top, white) and t-NADPH (bottom, black)
Citation: (2022) PLoS Computational Biology Issue Image | Vol. 18(2) February 2022. PLoS Comput Biol 18(2): ev18.i02. https://doi.org/10.1371/image.pcbi.v18.i02
Published: February 28, 2022
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High resolution structure of Staphyloccus aureus dihydrofolate reductase (DHFR) with inhibitor R-27 (top, white) and t-NADPH (bottom, black)
DHFR exploits this alternate anomeric configuration of NADPH to evade inhibition by certain inhibitors.
Image Credit: Graham Holt, Donald Laboratory, Duke University.