Figures
Computational modeling of blood cell transport in retinal microaneurysms
Retinal microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy (DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina that impacts visual function. In this work, the authors perform computational modeling of blood cell transport in microvessels containing various MAs, a process that is very difficult to observe directly in vivo. The simulation results provide quantitative assessments of the impacts of MA morphology, microvascular hematocrit, hemodynamics and blood cell biomechanics on the perfusion status of MA lumen and unravel the mechanisms underlying the MA rupture and thrombosis in DR.
Image Credit: This image is created by Dr. Chensen Lin and Dr. He Li and they own the copyright.
Citation: (2022) PLoS Computational Biology Issue Image | Vol. 18(1) January 2022. PLoS Comput Biol 18(1): ev18.i01. https://doi.org/10.1371/image.pcbi.v18.i01
Published: January 31, 2022
This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Retinal microaneurysms (MAs) are one of the earliest clinically visible signs of diabetic retinopathy (DR). MA leakage or rupture may precipitate local pathology in the surrounding neural retina that impacts visual function. In this work, the authors perform computational modeling of blood cell transport in microvessels containing various MAs, a process that is very difficult to observe directly in vivo. The simulation results provide quantitative assessments of the impacts of MA morphology, microvascular hematocrit, hemodynamics and blood cell biomechanics on the perfusion status of MA lumen and unravel the mechanisms underlying the MA rupture and thrombosis in DR.
Image Credit: This image is created by Dr. Chensen Lin and Dr. He Li and they own the copyright.