Figures
An experimentally validated regulatory network involving neurodevelopmental genes.
The elucidation of the transcriptional regulatory networks that orchestrate brain development is an important problem in systems biology. Biologists have performed reliable low-throughput investigations of regulatory interactions between transcription factors and target genes for decades, providing a deep source of information that is not fully exploited. Chu et al. reviewed over 3,000 research publications to document low-throughput experimental evidence for 1,499 unique regulatory interactions shown in the figure, involving 251 transcription factors (blue) and 825 targets (orange). Article
Image Credit: The network graphic was created by Eric Ching-Pan Chu (first author) using Cytoscape (Shannon et al., Genome Res 2003).
Citation: (2021) PLoS Computational Biology Issue Image | Vol. 17(10) October 2021. PLoS Comput Biol 17(10): ev17.i10. https://doi.org/10.1371/image.pcbi.v17.i10
Published: October 31, 2021
Copyright: © 2021 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The elucidation of the transcriptional regulatory networks that orchestrate brain development is an important problem in systems biology. Biologists have performed reliable low-throughput investigations of regulatory interactions between transcription factors and target genes for decades, providing a deep source of information that is not fully exploited. Chu et al. reviewed over 3,000 research publications to document low-throughput experimental evidence for 1,499 unique regulatory interactions shown in the figure, involving 251 transcription factors (blue) and 825 targets (orange). Article
Image Credit: The network graphic was created by Eric Ching-Pan Chu (first author) using Cytoscape (Shannon et al., Genome Res 2003).