Figures
Oxygen gradients in an artificial vascularized tumor perfused with hemoglobin-based oxygen carrier supplemented blood.
Hypoxia within solid tumors resulting from increased oxygen consumption and abnormal vascularization limits the effectiveness of cancer therapies. This image depicts the oxygen gradient of a hypoxic tumor growing in a vascularized bed interjacent of arterial and venous nodes. Here, the tumor has altered the vasculature, reducing venular oxygen transport. Using these models of vascular oxygen transport, Belcher et al explored how the tumor oxygenation potential of hemoglobin-based oxygen carriers (HBOCs) can differ between mice and humans. Specifically, they estimated which clinically measurable properties of the tumor may help translate HBOC facilitated tumor oxygenation from murine models to the clinic.
Image Credit: Donald Belcher, The Ohio State University
Citation: (2020) PLoS Computational Biology Issue Image | Vol. 16(8) September 2020. PLoS Comput Biol 16(8): ev16.i08. https://doi.org/10.1371/image.pcbi.v16.i08
Published: September 1, 2020
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hypoxia within solid tumors resulting from increased oxygen consumption and abnormal vascularization limits the effectiveness of cancer therapies. This image depicts the oxygen gradient of a hypoxic tumor growing in a vascularized bed interjacent of arterial and venous nodes. Here, the tumor has altered the vasculature, reducing venular oxygen transport. Using these models of vascular oxygen transport, Belcher et al explored how the tumor oxygenation potential of hemoglobin-based oxygen carriers (HBOCs) can differ between mice and humans. Specifically, they estimated which clinically measurable properties of the tumor may help translate HBOC facilitated tumor oxygenation from murine models to the clinic.
Image Credit: Donald Belcher, The Ohio State University