Figures
Increased fractions of stiffened red blood cells in flow decreases platelet margination
Many diseases are known to impede the deformability of the red blood cell, which may adversely impact the transport of red blood cells (red) and platelets (yellow) in flow. Czaja et al. observes with increasing fractions of stiffened red blood cells (purple) in flow, a decrease of platelet margination to the vessel wall. Specifically, this is observed as a decrease of a fluorescent platelet signal at the wall of a glass channel with flowing human whole blood, and confirmed via cell resolved simulations.
Image Credit: Benjamin Czaja, The University of Amsterdam
Citation: (2020) PLoS Computational Biology Issue Image | Vol. 16(3) March 2020. PLoS Comput Biol 16(3): ev16.i03. https://doi.org/10.1371/image.pcbi.v16.i03
Published: March 31, 2020
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Many diseases are known to impede the deformability of the red blood cell, which may adversely impact the transport of red blood cells (red) and platelets (yellow) in flow. Czaja et al. observes with increasing fractions of stiffened red blood cells (purple) in flow, a decrease of platelet margination to the vessel wall. Specifically, this is observed as a decrease of a fluorescent platelet signal at the wall of a glass channel with flowing human whole blood, and confirmed via cell resolved simulations.
Image Credit: Benjamin Czaja, The University of Amsterdam