Figures
Interaction fingerprint of hyaluronan and its CD44 receptor
The ubiquitous hyaluronan sugar binds to its native CD44 receptor, mediating cell-environment interactions. Hyaluronan can bind CD44 in three well-defined binding modes, each characterized by a pair of spatially separated arginine residues. The image shows one of the binding modes discovered using simulation techniques. Each mode might play a different functional role, e.g. in aggregation kinetics.Vuorio et al.
Image Credit: Vuorio et al.
Citation: (2017) PLoS Computational Biology Issue Image | Vol. 13(7) July 2017. PLoS Comput Biol 13(7): ev13.i07. https://doi.org/10.1371/image.pcbi.v13.i07
Published: July 31, 2017
Copyright: © 2017 Vuorio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The ubiquitous hyaluronan sugar binds to its native CD44 receptor, mediating cell-environment interactions. Hyaluronan can bind CD44 in three well-defined binding modes, each characterized by a pair of spatially separated arginine residues. The image shows one of the binding modes discovered using simulation techniques. Each mode might play a different functional role, e.g. in aggregation kinetics.Vuorio et al.
Image Credit: Vuorio et al.