Figures
Getting to know you: Innate immune sensing of fungal pathogen surfaces.
The earliest events in host defense against Candida species fungal pathogens involve the recruitment of anti-fungal receptors to specialized cellular contact sites. Image bioinformatic approaches permit quantitative dissection of spatiotemporal receptor distributions along this complex interface. Human immature dendritic cells (foreground right) recruit DC-SIGN (green) and CD206 (red) to capture C. albicans yeast (yellow), achieving up to two orders of magnitude enrichment of these receptors at the contact site. See Graus et al.
Image Credit: Matthew S. Graus, Aaron K. Neumann
Citation: (2014) PLoS Computational Biology Issue Image | Vol. 10(5) May 2014. PLoS Comput Biol 10(5): ev10.i05. https://doi.org/10.1371/image.pcbi.v10.i05
Published: May 29, 2014
Copyright: © 2014 Graus et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The earliest events in host defense against Candida species fungal pathogens involve the recruitment of anti-fungal receptors to specialized cellular contact sites. Image bioinformatic approaches permit quantitative dissection of spatiotemporal receptor distributions along this complex interface. Human immature dendritic cells (foreground right) recruit DC-SIGN (green) and CD206 (red) to capture C. albicans yeast (yellow), achieving up to two orders of magnitude enrichment of these receptors at the contact site. See Graus et al.
Image Credit: Matthew S. Graus, Aaron K. Neumann