Figures
Ensemble conformations of human Chromosome 19 generated by computer simulations
The yellow bundle in the foreground represents a coarse-grained, computer-generated conformation of human Chromosome 19. The structure was obtained by using steered molecular dynamics simulations to enforce a comprehensive set of knowledge-based constraints. Specifically, the simulations were used to promote the spatial proximity of hundreds of gene pairs that are known to be significantly co-regulated. Conformations were obtained with LAMMPS and visualized by VMD. See Di Stefano, et al.
Image Credit: Marco Di Stefano, Angelo Rosa, Cristian Micheletti
Citation: (2013) PLoS Computational Biology Issue Image | Vol. 9(3) March 2013. PLoS Comput Biol 9(3): ev09.i03. https://doi.org/10.1371/image.pcbi.v09.i03
Published: March 28, 2013
Copyright: © 2013 Di Stefano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The yellow bundle in the foreground represents a coarse-grained, computer-generated conformation of human Chromosome 19. The structure was obtained by using steered molecular dynamics simulations to enforce a comprehensive set of knowledge-based constraints. Specifically, the simulations were used to promote the spatial proximity of hundreds of gene pairs that are known to be significantly co-regulated. Conformations were obtained with LAMMPS and visualized by VMD. See Di Stefano, et al.
Image Credit: Marco Di Stefano, Angelo Rosa, Cristian Micheletti