Figures
Puzzling out the dynamical and mechanical stability of the dorsoventral organizer.
During development a cellular population, the so-called "organizer," ensures segregation of the cells that lead to the dorsal (D) and ventral (V) parts of the wing blade of Drosophila. In Canela-Xandri et al. (10.1371/journal.pcbi.1002153), the authors shed light on the mechanical and dynamical properties of cells necessary to perform such a task robustly as cells grow and proliferate. The study also unveils how the organizer is conveniently scaled as the wing tissue grows. The image artistically depicts a snapshot of the study's simulations: dorsal and ventral cells at the wing compartments bulk (white), organizer cells (red), and the so-called DV boundary (green line). In this study the authors used a dynamical vertex model that accounts for the forces acting on cells and that includes the modeling of the cell cycle duration and cleavage with stochastic variability. In summary, the paper presents a theoretical and computational approach for understanding, in a quantitative and predictive manner, the dynamics, structure, and stability of the DV organizer.
Image Credit: Javier Buceta, Computer Simulation and Modeling (Co.S.Mo.) Lab, Parc Cientific de Barcelona, Spain.
Citation: (2011) PLoS Computational Biology Issue Image | Vol. 7(9) September 2011. PLoS Comput Biol 7(9): ev07.i09. https://doi.org/10.1371/image.pcbi.v07.i09
Published: September 29, 2011
Copyright: © 2011 Buceta. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
During development a cellular population, the so-called "organizer," ensures segregation of the cells that lead to the dorsal (D) and ventral (V) parts of the wing blade of Drosophila. In Canela-Xandri et al. (10.1371/journal.pcbi.1002153), the authors shed light on the mechanical and dynamical properties of cells necessary to perform such a task robustly as cells grow and proliferate. The study also unveils how the organizer is conveniently scaled as the wing tissue grows. The image artistically depicts a snapshot of the study's simulations: dorsal and ventral cells at the wing compartments bulk (white), organizer cells (red), and the so-called DV boundary (green line). In this study the authors used a dynamical vertex model that accounts for the forces acting on cells and that includes the modeling of the cell cycle duration and cleavage with stochastic variability. In summary, the paper presents a theoretical and computational approach for understanding, in a quantitative and predictive manner, the dynamics, structure, and stability of the DV organizer.
Image Credit: Javier Buceta, Computer Simulation and Modeling (Co.S.Mo.) Lab, Parc Cientific de Barcelona, Spain.