Figures
Predicted distribution of methylation patterns in a non-hierarchical versus a cancer stem cell driven tumor.
In the top right image the simulated methylation patterns in a nonhierarchical (classical) malignancy, indicated with different colors, radiate outward from the center. In the bottom left image, in contrast, the patterns occurring in a hierarchical (CSC-driven) tumor spread as patch-like colonies, increasing the overall intratumor heterogeneity and greatly affecting the evolutionary properties of the cancer cell population. (See Sottoriva et al., doi: 10.1371/journal.pcbi.1001132)
Image Credit: Andrea Sottoriva, Cambridge University, United Kingdom
Citation: (2011) PLoS Computational Biology Issue Image | Vol. 7(5) May 2011. PLoS Comput Biol 7(5): ev07.i05. https://doi.org/10.1371/image.pcbi.v07.i05
Published: May 26, 2011
Copyright: © 2011 Sottoriva et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the top right image the simulated methylation patterns in a nonhierarchical (classical) malignancy, indicated with different colors, radiate outward from the center. In the bottom left image, in contrast, the patterns occurring in a hierarchical (CSC-driven) tumor spread as patch-like colonies, increasing the overall intratumor heterogeneity and greatly affecting the evolutionary properties of the cancer cell population. (See Sottoriva et al., doi: 10.1371/journal.pcbi.1001132)
Image Credit: Andrea Sottoriva, Cambridge University, United Kingdom