Figures
Long-range correlated motions are essential for nuclear receptor activity.
AF-2 domains of nuclear receptors mediate crucial protein–protein interactions with transcriptional coactivators. The AF-2 domains (magenta) of the human nuclear xenobiotic receptor PXR (cyan) were demonstrated using molecular dynamics to move together in an "active-ready" conformation, poised to bind to their cognate protein partners (see Teotico et al. pcbi.1000111). Other nuclear receptors were also shown to follow suit.
Image Credit: Monica Frazier and Matthew Redinbo
Citation: (2008) PLoS Computational Biology Issue Image | Vol. 4(7) July 2008. PLoS Comput Biol 4(7): ev04.i07. https://doi.org/10.1371/image.pcbi.v04.i07
Published: July 25, 2008
Copyright: © 2008 Teotico et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
AF-2 domains of nuclear receptors mediate crucial protein–protein interactions with transcriptional coactivators. The AF-2 domains (magenta) of the human nuclear xenobiotic receptor PXR (cyan) were demonstrated using molecular dynamics to move together in an "active-ready" conformation, poised to bind to their cognate protein partners (see Teotico et al. pcbi.1000111). Other nuclear receptors were also shown to follow suit.
Image Credit: Monica Frazier and Matthew Redinbo