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Trinucleotide disease as a genetic time bomb
A trinucleotide disease is like a genetic time bomb. A patient with such a disease inherits a DNA region consisting of a three-letter code repeated abnormally many times. The age at which the disease strikes the patient is encoded by the number of repeats. A universal mechanism by which this molecular time bomb operates in this broad family of hereditary diseases has been suggested (see Kaplan et al, e235).
Image Credit: Genia Brodsky, Weizmann Institute of Science
Citation: (2007) PLoS Computational Biology Issue Image | Vol. 3(11) November 2007. PLoS Comput Biol 3(11): ev03.i11. https://doi.org/10.1371/image.pcbi.v03.i11
Published: November 30, 2007
Copyright: © 2007 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A trinucleotide disease is like a genetic time bomb. A patient with such a disease inherits a DNA region consisting of a three-letter code repeated abnormally many times. The age at which the disease strikes the patient is encoded by the number of repeats. A universal mechanism by which this molecular time bomb operates in this broad family of hereditary diseases has been suggested (see Kaplan et al, e235).
Image Credit: Genia Brodsky, Weizmann Institute of Science